Potential therapeutic role of SIRT1 in age- related hearing loss

Age-related hearing loss (ARHL) is a major public health burden worldwide that profoundly affects the daily life of elderly people. Silent information regulator 1 (SIRT1 or Sirtuin1), known as a regulator of the cell cycle, the balance of oxidation/antioxidant and mitochondrial function, has been pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Tingting, Tian, Guangyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530142/
https://www.ncbi.nlm.nih.gov/pubmed/36204138
http://dx.doi.org/10.3389/fnmol.2022.984292
_version_ 1784801612809633792
author Zhao, Tingting
Tian, Guangyong
author_facet Zhao, Tingting
Tian, Guangyong
author_sort Zhao, Tingting
collection PubMed
description Age-related hearing loss (ARHL) is a major public health burden worldwide that profoundly affects the daily life of elderly people. Silent information regulator 1 (SIRT1 or Sirtuin1), known as a regulator of the cell cycle, the balance of oxidation/antioxidant and mitochondrial function, has been proven to have anti-aging and life-extending effects, and its possible connection with ARHL has received increasing attention in recent years. This paper provides an overview of research on the connection between SIRT1 and ARHL. Topics cover both the functions of SIRT1 and its important role in ARHL. This review concludes with a look at possible research directions for ARHL in the future.
format Online
Article
Text
id pubmed-9530142
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95301422022-10-05 Potential therapeutic role of SIRT1 in age- related hearing loss Zhao, Tingting Tian, Guangyong Front Mol Neurosci Neuroscience Age-related hearing loss (ARHL) is a major public health burden worldwide that profoundly affects the daily life of elderly people. Silent information regulator 1 (SIRT1 or Sirtuin1), known as a regulator of the cell cycle, the balance of oxidation/antioxidant and mitochondrial function, has been proven to have anti-aging and life-extending effects, and its possible connection with ARHL has received increasing attention in recent years. This paper provides an overview of research on the connection between SIRT1 and ARHL. Topics cover both the functions of SIRT1 and its important role in ARHL. This review concludes with a look at possible research directions for ARHL in the future. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530142/ /pubmed/36204138 http://dx.doi.org/10.3389/fnmol.2022.984292 Text en Copyright © 2022 Zhao and Tian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhao, Tingting
Tian, Guangyong
Potential therapeutic role of SIRT1 in age- related hearing loss
title Potential therapeutic role of SIRT1 in age- related hearing loss
title_full Potential therapeutic role of SIRT1 in age- related hearing loss
title_fullStr Potential therapeutic role of SIRT1 in age- related hearing loss
title_full_unstemmed Potential therapeutic role of SIRT1 in age- related hearing loss
title_short Potential therapeutic role of SIRT1 in age- related hearing loss
title_sort potential therapeutic role of sirt1 in age- related hearing loss
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530142/
https://www.ncbi.nlm.nih.gov/pubmed/36204138
http://dx.doi.org/10.3389/fnmol.2022.984292
work_keys_str_mv AT zhaotingting potentialtherapeuticroleofsirt1inagerelatedhearingloss
AT tianguangyong potentialtherapeuticroleofsirt1inagerelatedhearingloss

Ejemplares similares