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MutS functions as a clamp loader by positioning MutL on the DNA during mismatch repair

Highly conserved MutS and MutL homologs operate as protein dimers in mismatch repair (MMR). MutS recognizes mismatched nucleotides forming ATP-bound sliding clamps, which subsequently load MutL sliding clamps that coordinate MMR excision. Several MMR models envision static MutS-MutL complexes bound...

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Detalles Bibliográficos
Autores principales:	Yang, Xiao-Wen, Han, Xiao-Peng, Han, Chong, London, James, Fishel, Richard, Liu, Jiaquan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530208/ https://www.ncbi.nlm.nih.gov/pubmed/36192430 http://dx.doi.org/10.1038/s41467-022-33479-3

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