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Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw

Surgical trauma in those under a prolonged use of bisphosphonates, can lead to mediation-related osteonecrosis of the jaw (MRONJ). This study aimed to evaluate the preventive therapies for MRONJ. Following four cycles of zoledronic acid administration, Wistar rats had their molar extracted, and were...

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Autores principales: Hadad, Henrique, Kawamata de Jesus, Laís, Piquera Santos, Ana Flávia, Rinaldi Matheus, Henrique, de Souza Rodrigues, Letícia Gabriella, Paolo Poli, Pier, Marcantonio Junior, Elcio, Pozzi Semeghini Guastaldi, Fernando, Maiorana, Carlo, Milanezi de Almeida, Juliano, Okamoto, Roberta, Ávila Souza, Francisley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530223/
https://www.ncbi.nlm.nih.gov/pubmed/36192619
http://dx.doi.org/10.1038/s41598-022-20128-4
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author Hadad, Henrique
Kawamata de Jesus, Laís
Piquera Santos, Ana Flávia
Rinaldi Matheus, Henrique
de Souza Rodrigues, Letícia Gabriella
Paolo Poli, Pier
Marcantonio Junior, Elcio
Pozzi Semeghini Guastaldi, Fernando
Maiorana, Carlo
Milanezi de Almeida, Juliano
Okamoto, Roberta
Ávila Souza, Francisley
author_facet Hadad, Henrique
Kawamata de Jesus, Laís
Piquera Santos, Ana Flávia
Rinaldi Matheus, Henrique
de Souza Rodrigues, Letícia Gabriella
Paolo Poli, Pier
Marcantonio Junior, Elcio
Pozzi Semeghini Guastaldi, Fernando
Maiorana, Carlo
Milanezi de Almeida, Juliano
Okamoto, Roberta
Ávila Souza, Francisley
author_sort Hadad, Henrique
collection PubMed
description Surgical trauma in those under a prolonged use of bisphosphonates, can lead to mediation-related osteonecrosis of the jaw (MRONJ). This study aimed to evaluate the preventive therapies for MRONJ. Following four cycles of zoledronic acid administration, Wistar rats had their molar extracted, and were organized into nine treatment groups: negative control group (NCG), treated with saline solution and blood-clot in the alveolus; positive control group (PCG), with blood-clot in the alveolus; BG, β-tricalcium phosphate-based biomaterial; DG, 10% doxycycline gel; aG, antimicrobial photodynamic therapy; and DBG, aBG, aDG, and aDBG, using combination therapy. After 28 days, the lowest bone volume (BV/TV) was reported in PCG (42.17% ± 2.65), and the highest in aDBG (69.85% ± 6.25) (p < 0.05). The higher values of daily mineral apposition rate were recorded in aDBG (2.64 ± 0.48) and DBG (2.30 ± 0.37) (p < 0.001). Moreover, aDBG presented with the highest neoformed bone area (82.44% ± 2.69) (p < 0.05). Non-vital bone was reported only in the PCG (37.94 ± 18.70%). Owing to the key role of the biomaterial, the combination approach (aDBG) was the most effective in preventing MRONJ following tooth extraction.
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spelling pubmed-95302232022-10-05 Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw Hadad, Henrique Kawamata de Jesus, Laís Piquera Santos, Ana Flávia Rinaldi Matheus, Henrique de Souza Rodrigues, Letícia Gabriella Paolo Poli, Pier Marcantonio Junior, Elcio Pozzi Semeghini Guastaldi, Fernando Maiorana, Carlo Milanezi de Almeida, Juliano Okamoto, Roberta Ávila Souza, Francisley Sci Rep Article Surgical trauma in those under a prolonged use of bisphosphonates, can lead to mediation-related osteonecrosis of the jaw (MRONJ). This study aimed to evaluate the preventive therapies for MRONJ. Following four cycles of zoledronic acid administration, Wistar rats had their molar extracted, and were organized into nine treatment groups: negative control group (NCG), treated with saline solution and blood-clot in the alveolus; positive control group (PCG), with blood-clot in the alveolus; BG, β-tricalcium phosphate-based biomaterial; DG, 10% doxycycline gel; aG, antimicrobial photodynamic therapy; and DBG, aBG, aDG, and aDBG, using combination therapy. After 28 days, the lowest bone volume (BV/TV) was reported in PCG (42.17% ± 2.65), and the highest in aDBG (69.85% ± 6.25) (p < 0.05). The higher values of daily mineral apposition rate were recorded in aDBG (2.64 ± 0.48) and DBG (2.30 ± 0.37) (p < 0.001). Moreover, aDBG presented with the highest neoformed bone area (82.44% ± 2.69) (p < 0.05). Non-vital bone was reported only in the PCG (37.94 ± 18.70%). Owing to the key role of the biomaterial, the combination approach (aDBG) was the most effective in preventing MRONJ following tooth extraction. Nature Publishing Group UK 2022-10-03 /pmc/articles/PMC9530223/ /pubmed/36192619 http://dx.doi.org/10.1038/s41598-022-20128-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hadad, Henrique
Kawamata de Jesus, Laís
Piquera Santos, Ana Flávia
Rinaldi Matheus, Henrique
de Souza Rodrigues, Letícia Gabriella
Paolo Poli, Pier
Marcantonio Junior, Elcio
Pozzi Semeghini Guastaldi, Fernando
Maiorana, Carlo
Milanezi de Almeida, Juliano
Okamoto, Roberta
Ávila Souza, Francisley
Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw
title Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw
title_full Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw
title_fullStr Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw
title_full_unstemmed Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw
title_short Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw
title_sort beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530223/
https://www.ncbi.nlm.nih.gov/pubmed/36192619
http://dx.doi.org/10.1038/s41598-022-20128-4
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