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Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw
Surgical trauma in those under a prolonged use of bisphosphonates, can lead to mediation-related osteonecrosis of the jaw (MRONJ). This study aimed to evaluate the preventive therapies for MRONJ. Following four cycles of zoledronic acid administration, Wistar rats had their molar extracted, and were...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530223/ https://www.ncbi.nlm.nih.gov/pubmed/36192619 http://dx.doi.org/10.1038/s41598-022-20128-4 |
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author | Hadad, Henrique Kawamata de Jesus, Laís Piquera Santos, Ana Flávia Rinaldi Matheus, Henrique de Souza Rodrigues, Letícia Gabriella Paolo Poli, Pier Marcantonio Junior, Elcio Pozzi Semeghini Guastaldi, Fernando Maiorana, Carlo Milanezi de Almeida, Juliano Okamoto, Roberta Ávila Souza, Francisley |
author_facet | Hadad, Henrique Kawamata de Jesus, Laís Piquera Santos, Ana Flávia Rinaldi Matheus, Henrique de Souza Rodrigues, Letícia Gabriella Paolo Poli, Pier Marcantonio Junior, Elcio Pozzi Semeghini Guastaldi, Fernando Maiorana, Carlo Milanezi de Almeida, Juliano Okamoto, Roberta Ávila Souza, Francisley |
author_sort | Hadad, Henrique |
collection | PubMed |
description | Surgical trauma in those under a prolonged use of bisphosphonates, can lead to mediation-related osteonecrosis of the jaw (MRONJ). This study aimed to evaluate the preventive therapies for MRONJ. Following four cycles of zoledronic acid administration, Wistar rats had their molar extracted, and were organized into nine treatment groups: negative control group (NCG), treated with saline solution and blood-clot in the alveolus; positive control group (PCG), with blood-clot in the alveolus; BG, β-tricalcium phosphate-based biomaterial; DG, 10% doxycycline gel; aG, antimicrobial photodynamic therapy; and DBG, aBG, aDG, and aDBG, using combination therapy. After 28 days, the lowest bone volume (BV/TV) was reported in PCG (42.17% ± 2.65), and the highest in aDBG (69.85% ± 6.25) (p < 0.05). The higher values of daily mineral apposition rate were recorded in aDBG (2.64 ± 0.48) and DBG (2.30 ± 0.37) (p < 0.001). Moreover, aDBG presented with the highest neoformed bone area (82.44% ± 2.69) (p < 0.05). Non-vital bone was reported only in the PCG (37.94 ± 18.70%). Owing to the key role of the biomaterial, the combination approach (aDBG) was the most effective in preventing MRONJ following tooth extraction. |
format | Online Article Text |
id | pubmed-9530223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-95302232022-10-05 Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw Hadad, Henrique Kawamata de Jesus, Laís Piquera Santos, Ana Flávia Rinaldi Matheus, Henrique de Souza Rodrigues, Letícia Gabriella Paolo Poli, Pier Marcantonio Junior, Elcio Pozzi Semeghini Guastaldi, Fernando Maiorana, Carlo Milanezi de Almeida, Juliano Okamoto, Roberta Ávila Souza, Francisley Sci Rep Article Surgical trauma in those under a prolonged use of bisphosphonates, can lead to mediation-related osteonecrosis of the jaw (MRONJ). This study aimed to evaluate the preventive therapies for MRONJ. Following four cycles of zoledronic acid administration, Wistar rats had their molar extracted, and were organized into nine treatment groups: negative control group (NCG), treated with saline solution and blood-clot in the alveolus; positive control group (PCG), with blood-clot in the alveolus; BG, β-tricalcium phosphate-based biomaterial; DG, 10% doxycycline gel; aG, antimicrobial photodynamic therapy; and DBG, aBG, aDG, and aDBG, using combination therapy. After 28 days, the lowest bone volume (BV/TV) was reported in PCG (42.17% ± 2.65), and the highest in aDBG (69.85% ± 6.25) (p < 0.05). The higher values of daily mineral apposition rate were recorded in aDBG (2.64 ± 0.48) and DBG (2.30 ± 0.37) (p < 0.001). Moreover, aDBG presented with the highest neoformed bone area (82.44% ± 2.69) (p < 0.05). Non-vital bone was reported only in the PCG (37.94 ± 18.70%). Owing to the key role of the biomaterial, the combination approach (aDBG) was the most effective in preventing MRONJ following tooth extraction. Nature Publishing Group UK 2022-10-03 /pmc/articles/PMC9530223/ /pubmed/36192619 http://dx.doi.org/10.1038/s41598-022-20128-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hadad, Henrique Kawamata de Jesus, Laís Piquera Santos, Ana Flávia Rinaldi Matheus, Henrique de Souza Rodrigues, Letícia Gabriella Paolo Poli, Pier Marcantonio Junior, Elcio Pozzi Semeghini Guastaldi, Fernando Maiorana, Carlo Milanezi de Almeida, Juliano Okamoto, Roberta Ávila Souza, Francisley Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw |
title | Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw |
title_full | Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw |
title_fullStr | Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw |
title_full_unstemmed | Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw |
title_short | Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw |
title_sort | beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530223/ https://www.ncbi.nlm.nih.gov/pubmed/36192619 http://dx.doi.org/10.1038/s41598-022-20128-4 |
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