Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy

The function of interleukin-22 (IL-22) in intestinal barrier homeostasis remains controversial. Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial organoids and evaluate the biological, functional and clinical significance of the IL-22 mediated pathways in ulce...

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Detalles Bibliográficos
Autores principales: Pavlidis, Polychronis, Tsakmaki, Anastasia, Pantazi, Eirini, Li, Katherine, Cozzetto, Domenico, Digby- Bell, Jonathan, Yang, Feifei, Lo, Jonathan W., Alberts, Elena, Sa, Ana Caroline Costa, Niazi, Umar, Friedman, Joshua, Long, Anna K., Ding, Yuchun, Carey, Christopher D., Lamb, Christopher, Saqi, Mansoor, Madgwick, Matthew, Gul, Leila, Treveil, Agatha, Korcsmaros, Tamas, Macdonald, Thomas T., Lord, Graham M., Bewick, Gavin, Powell, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530232/
https://www.ncbi.nlm.nih.gov/pubmed/36192482
http://dx.doi.org/10.1038/s41467-022-33331-8

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