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Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases

Carbohydrates serve as important energy sources and structural substances for human body as well as for gut microbes. As evidenced by the advances in immunometabolism, glucose metabolism and adenosine triphosphate (ATP) generation are deeply involved in immune cell activation, proliferation, and sig...

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Autores principales: Wang, Lu, Xu, Haojie, Yang, Huaxia, Zhou, Jiaxin, Zhao, Lidan, Zhang, Fengchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530352/
https://www.ncbi.nlm.nih.gov/pubmed/36203617
http://dx.doi.org/10.3389/fimmu.2022.952398
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author Wang, Lu
Xu, Haojie
Yang, Huaxia
Zhou, Jiaxin
Zhao, Lidan
Zhang, Fengchun
author_facet Wang, Lu
Xu, Haojie
Yang, Huaxia
Zhou, Jiaxin
Zhao, Lidan
Zhang, Fengchun
author_sort Wang, Lu
collection PubMed
description Carbohydrates serve as important energy sources and structural substances for human body as well as for gut microbes. As evidenced by the advances in immunometabolism, glucose metabolism and adenosine triphosphate (ATP) generation are deeply involved in immune cell activation, proliferation, and signaling transduction as well as trafficking and effector functions, thus contributing to immune response programming and assisting in host adaption to microenvironment changes. Increased glucose uptake, aberrant expression of glucose transporter 1 (e.g., GLU1), and abnormal glycosylation patterns have been identified in autoimmunity and are suggested as partially responsible for the dysregulated immune response and the modification of gut microbiome composition in the autoimmune pathogenesis. The interaction between gut microbiota and host carbohydrate metabolism is complex and bidirectional. Their impact on host immune homeostasis and the development of autoimmune diseases remains to be elucidated. This review summarized the current knowledge on the crosstalk of glucose metabolism and glycosylation in the host with intestinal microbiota and discussed their possible role in the development and progression of autoimmune diseases. Potential therapeutic strategies targeting glucose metabolism and glycosylation in modulating gut ecosystem and treating autoimmune diseases were discussed as well.
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spelling pubmed-95303522022-10-05 Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases Wang, Lu Xu, Haojie Yang, Huaxia Zhou, Jiaxin Zhao, Lidan Zhang, Fengchun Front Immunol Immunology Carbohydrates serve as important energy sources and structural substances for human body as well as for gut microbes. As evidenced by the advances in immunometabolism, glucose metabolism and adenosine triphosphate (ATP) generation are deeply involved in immune cell activation, proliferation, and signaling transduction as well as trafficking and effector functions, thus contributing to immune response programming and assisting in host adaption to microenvironment changes. Increased glucose uptake, aberrant expression of glucose transporter 1 (e.g., GLU1), and abnormal glycosylation patterns have been identified in autoimmunity and are suggested as partially responsible for the dysregulated immune response and the modification of gut microbiome composition in the autoimmune pathogenesis. The interaction between gut microbiota and host carbohydrate metabolism is complex and bidirectional. Their impact on host immune homeostasis and the development of autoimmune diseases remains to be elucidated. This review summarized the current knowledge on the crosstalk of glucose metabolism and glycosylation in the host with intestinal microbiota and discussed their possible role in the development and progression of autoimmune diseases. Potential therapeutic strategies targeting glucose metabolism and glycosylation in modulating gut ecosystem and treating autoimmune diseases were discussed as well. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530352/ /pubmed/36203617 http://dx.doi.org/10.3389/fimmu.2022.952398 Text en Copyright © 2022 Wang, Xu, Yang, Zhou, Zhao and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Lu
Xu, Haojie
Yang, Huaxia
Zhou, Jiaxin
Zhao, Lidan
Zhang, Fengchun
Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases
title Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases
title_full Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases
title_fullStr Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases
title_full_unstemmed Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases
title_short Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases
title_sort glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530352/
https://www.ncbi.nlm.nih.gov/pubmed/36203617
http://dx.doi.org/10.3389/fimmu.2022.952398
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