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Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases
Carbohydrates serve as important energy sources and structural substances for human body as well as for gut microbes. As evidenced by the advances in immunometabolism, glucose metabolism and adenosine triphosphate (ATP) generation are deeply involved in immune cell activation, proliferation, and sig...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530352/ https://www.ncbi.nlm.nih.gov/pubmed/36203617 http://dx.doi.org/10.3389/fimmu.2022.952398 |
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author | Wang, Lu Xu, Haojie Yang, Huaxia Zhou, Jiaxin Zhao, Lidan Zhang, Fengchun |
author_facet | Wang, Lu Xu, Haojie Yang, Huaxia Zhou, Jiaxin Zhao, Lidan Zhang, Fengchun |
author_sort | Wang, Lu |
collection | PubMed |
description | Carbohydrates serve as important energy sources and structural substances for human body as well as for gut microbes. As evidenced by the advances in immunometabolism, glucose metabolism and adenosine triphosphate (ATP) generation are deeply involved in immune cell activation, proliferation, and signaling transduction as well as trafficking and effector functions, thus contributing to immune response programming and assisting in host adaption to microenvironment changes. Increased glucose uptake, aberrant expression of glucose transporter 1 (e.g., GLU1), and abnormal glycosylation patterns have been identified in autoimmunity and are suggested as partially responsible for the dysregulated immune response and the modification of gut microbiome composition in the autoimmune pathogenesis. The interaction between gut microbiota and host carbohydrate metabolism is complex and bidirectional. Their impact on host immune homeostasis and the development of autoimmune diseases remains to be elucidated. This review summarized the current knowledge on the crosstalk of glucose metabolism and glycosylation in the host with intestinal microbiota and discussed their possible role in the development and progression of autoimmune diseases. Potential therapeutic strategies targeting glucose metabolism and glycosylation in modulating gut ecosystem and treating autoimmune diseases were discussed as well. |
format | Online Article Text |
id | pubmed-9530352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95303522022-10-05 Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases Wang, Lu Xu, Haojie Yang, Huaxia Zhou, Jiaxin Zhao, Lidan Zhang, Fengchun Front Immunol Immunology Carbohydrates serve as important energy sources and structural substances for human body as well as for gut microbes. As evidenced by the advances in immunometabolism, glucose metabolism and adenosine triphosphate (ATP) generation are deeply involved in immune cell activation, proliferation, and signaling transduction as well as trafficking and effector functions, thus contributing to immune response programming and assisting in host adaption to microenvironment changes. Increased glucose uptake, aberrant expression of glucose transporter 1 (e.g., GLU1), and abnormal glycosylation patterns have been identified in autoimmunity and are suggested as partially responsible for the dysregulated immune response and the modification of gut microbiome composition in the autoimmune pathogenesis. The interaction between gut microbiota and host carbohydrate metabolism is complex and bidirectional. Their impact on host immune homeostasis and the development of autoimmune diseases remains to be elucidated. This review summarized the current knowledge on the crosstalk of glucose metabolism and glycosylation in the host with intestinal microbiota and discussed their possible role in the development and progression of autoimmune diseases. Potential therapeutic strategies targeting glucose metabolism and glycosylation in modulating gut ecosystem and treating autoimmune diseases were discussed as well. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530352/ /pubmed/36203617 http://dx.doi.org/10.3389/fimmu.2022.952398 Text en Copyright © 2022 Wang, Xu, Yang, Zhou, Zhao and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wang, Lu Xu, Haojie Yang, Huaxia Zhou, Jiaxin Zhao, Lidan Zhang, Fengchun Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases |
title | Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases |
title_full | Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases |
title_fullStr | Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases |
title_full_unstemmed | Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases |
title_short | Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases |
title_sort | glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530352/ https://www.ncbi.nlm.nih.gov/pubmed/36203617 http://dx.doi.org/10.3389/fimmu.2022.952398 |
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