NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma

Phosphoribosyl pyrophosphate synthetase 1 (PRPS1) is the first enzyme in the de novo purine nucleotide synthesis pathway and is essential for cell development. However, the effect of PRPS1 on melanoma proliferation and metastasis remains unclear. This study aimed to investigate the regulatory mechan...

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Autores principales: Xiong, Guohang, Feng, Yu, Yi, Xiaojia, Zhang, Xuedan, Li, Xiaoyu, Yang, Lijuan, Yi, Zihan, Sai, Buqing, Yang, Zhe, Zhang, Qiao, Kuang, Yingmin, Zhu, Yuechun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530353/
https://www.ncbi.nlm.nih.gov/pubmed/36203561
http://dx.doi.org/10.3389/fimmu.2022.989263
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author Xiong, Guohang
Feng, Yu
Yi, Xiaojia
Zhang, Xuedan
Li, Xiaoyu
Yang, Lijuan
Yi, Zihan
Sai, Buqing
Yang, Zhe
Zhang, Qiao
Kuang, Yingmin
Zhu, Yuechun
author_facet Xiong, Guohang
Feng, Yu
Yi, Xiaojia
Zhang, Xuedan
Li, Xiaoyu
Yang, Lijuan
Yi, Zihan
Sai, Buqing
Yang, Zhe
Zhang, Qiao
Kuang, Yingmin
Zhu, Yuechun
author_sort Xiong, Guohang
collection PubMed
description Phosphoribosyl pyrophosphate synthetase 1 (PRPS1) is the first enzyme in the de novo purine nucleotide synthesis pathway and is essential for cell development. However, the effect of PRPS1 on melanoma proliferation and metastasis remains unclear. This study aimed to investigate the regulatory mechanism of PRPS1 in the malignant progression of melanoma. Here, we found PRPS1 was upregulated in melanoma and melanoma cells. In addition, our data indicated that PRPS1 could promote the proliferation and migration and invasion of melanoma both in vitro and in vivo. PRPS1 also could inhibit melanoma cell apoptosis. Furthermore, we found NRF2 is an upstream transcription factor of PRPS1 that drive malignant progression of melanoma.
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spelling pubmed-95303532022-10-05 NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma Xiong, Guohang Feng, Yu Yi, Xiaojia Zhang, Xuedan Li, Xiaoyu Yang, Lijuan Yi, Zihan Sai, Buqing Yang, Zhe Zhang, Qiao Kuang, Yingmin Zhu, Yuechun Front Immunol Immunology Phosphoribosyl pyrophosphate synthetase 1 (PRPS1) is the first enzyme in the de novo purine nucleotide synthesis pathway and is essential for cell development. However, the effect of PRPS1 on melanoma proliferation and metastasis remains unclear. This study aimed to investigate the regulatory mechanism of PRPS1 in the malignant progression of melanoma. Here, we found PRPS1 was upregulated in melanoma and melanoma cells. In addition, our data indicated that PRPS1 could promote the proliferation and migration and invasion of melanoma both in vitro and in vivo. PRPS1 also could inhibit melanoma cell apoptosis. Furthermore, we found NRF2 is an upstream transcription factor of PRPS1 that drive malignant progression of melanoma. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530353/ /pubmed/36203561 http://dx.doi.org/10.3389/fimmu.2022.989263 Text en Copyright © 2022 Xiong, Feng, Yi, Zhang, Li, Yang, Yi, Sai, Yang, Zhang, Kuang and Zhu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Xiong, Guohang
Feng, Yu
Yi, Xiaojia
Zhang, Xuedan
Li, Xiaoyu
Yang, Lijuan
Yi, Zihan
Sai, Buqing
Yang, Zhe
Zhang, Qiao
Kuang, Yingmin
Zhu, Yuechun
NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma
title NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma
title_full NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma
title_fullStr NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma
title_full_unstemmed NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma
title_short NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma
title_sort nrf2-directed prps1 upregulation to promote the progression and metastasis of melanoma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530353/
https://www.ncbi.nlm.nih.gov/pubmed/36203561
http://dx.doi.org/10.3389/fimmu.2022.989263
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