Cargando…

Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn’s disease

Crohn’s disease (CD) is a chronic and relapsing inflammatory bowel disorder that has been shown to generate neurological impairments, which has the potential to signify disease activity in an underlying neurological manner. The objective of this study was to investigate the abnormalities of brain mi...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Yage, Li, Qingshang, Wu, Dongmei, Zhang, Yiming, Cheng, Jiahui, Cao, Zhijun, Zhou, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530355/
https://www.ncbi.nlm.nih.gov/pubmed/36203806
http://dx.doi.org/10.3389/fnins.2022.985190
_version_ 1784801664336658432
author Qiu, Yage
Li, Qingshang
Wu, Dongmei
Zhang, Yiming
Cheng, Jiahui
Cao, Zhijun
Zhou, Yan
author_facet Qiu, Yage
Li, Qingshang
Wu, Dongmei
Zhang, Yiming
Cheng, Jiahui
Cao, Zhijun
Zhou, Yan
author_sort Qiu, Yage
collection PubMed
description Crohn’s disease (CD) is a chronic and relapsing inflammatory bowel disorder that has been shown to generate neurological impairments, which has the potential to signify disease activity in an underlying neurological manner. The objective of this study was to investigate the abnormalities of brain microstructure and the corresponding functional connectivity (FC) in patients with CD, as well as their associations with disease condition. Twenty-two patients with CD and 22 age-, gender-, and education-matched healthy controls (HCs) were enrolled in this study. All subjects underwent mean apparent propagator (MAP)-MRI and resting-state functional magnetic resonance imaging (MRI) (rs-fMRI) data collection. Each patient was evaluated clinically for the condition and duration of the disease. The MAP metrics were extracted and compared between two groups. Pearson’s correlation analysis was conducted to determine the relationship between disease characteristics and significantly abnormal MAP metrics in the CD group. Regions of interest (ROIs) for ROI-wise FC analysis were selected based on their correlation with MAP metrics. Results showed that multiple brain regions, including the parahippocampus and thalamus, exhibited statistically significant differences in MAP metrics between CD patients and HCs. Additionally, CD patients exhibited decreased FC between the left parahippocampus and bilateral thalamus, as well as the right parahippocampus and bilateral thalamus. The findings of this work provide preliminary evidence that structural abnormalities in the parahippocampal gyrus (PHG) and thalamus, as well as decreased FC between them, may reflect the degree of inflammatory of the disease and serve as brain biomarkers for evaluating CD activity.
format Online
Article
Text
id pubmed-9530355
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95303552022-10-05 Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn’s disease Qiu, Yage Li, Qingshang Wu, Dongmei Zhang, Yiming Cheng, Jiahui Cao, Zhijun Zhou, Yan Front Neurosci Neuroscience Crohn’s disease (CD) is a chronic and relapsing inflammatory bowel disorder that has been shown to generate neurological impairments, which has the potential to signify disease activity in an underlying neurological manner. The objective of this study was to investigate the abnormalities of brain microstructure and the corresponding functional connectivity (FC) in patients with CD, as well as their associations with disease condition. Twenty-two patients with CD and 22 age-, gender-, and education-matched healthy controls (HCs) were enrolled in this study. All subjects underwent mean apparent propagator (MAP)-MRI and resting-state functional magnetic resonance imaging (MRI) (rs-fMRI) data collection. Each patient was evaluated clinically for the condition and duration of the disease. The MAP metrics were extracted and compared between two groups. Pearson’s correlation analysis was conducted to determine the relationship between disease characteristics and significantly abnormal MAP metrics in the CD group. Regions of interest (ROIs) for ROI-wise FC analysis were selected based on their correlation with MAP metrics. Results showed that multiple brain regions, including the parahippocampus and thalamus, exhibited statistically significant differences in MAP metrics between CD patients and HCs. Additionally, CD patients exhibited decreased FC between the left parahippocampus and bilateral thalamus, as well as the right parahippocampus and bilateral thalamus. The findings of this work provide preliminary evidence that structural abnormalities in the parahippocampal gyrus (PHG) and thalamus, as well as decreased FC between them, may reflect the degree of inflammatory of the disease and serve as brain biomarkers for evaluating CD activity. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530355/ /pubmed/36203806 http://dx.doi.org/10.3389/fnins.2022.985190 Text en Copyright © 2022 Qiu, Li, Wu, Zhang, Cheng, Cao and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Qiu, Yage
Li, Qingshang
Wu, Dongmei
Zhang, Yiming
Cheng, Jiahui
Cao, Zhijun
Zhou, Yan
Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn’s disease
title Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn’s disease
title_full Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn’s disease
title_fullStr Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn’s disease
title_full_unstemmed Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn’s disease
title_short Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn’s disease
title_sort altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in crohn’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530355/
https://www.ncbi.nlm.nih.gov/pubmed/36203806
http://dx.doi.org/10.3389/fnins.2022.985190
work_keys_str_mv AT qiuyage alteredmeanapparentpropagatorbasedmicrostructureandthecorrespondingfunctionalconnectivityoftheparahippocampusandthalamusincrohnsdisease
AT liqingshang alteredmeanapparentpropagatorbasedmicrostructureandthecorrespondingfunctionalconnectivityoftheparahippocampusandthalamusincrohnsdisease
AT wudongmei alteredmeanapparentpropagatorbasedmicrostructureandthecorrespondingfunctionalconnectivityoftheparahippocampusandthalamusincrohnsdisease
AT zhangyiming alteredmeanapparentpropagatorbasedmicrostructureandthecorrespondingfunctionalconnectivityoftheparahippocampusandthalamusincrohnsdisease
AT chengjiahui alteredmeanapparentpropagatorbasedmicrostructureandthecorrespondingfunctionalconnectivityoftheparahippocampusandthalamusincrohnsdisease
AT caozhijun alteredmeanapparentpropagatorbasedmicrostructureandthecorrespondingfunctionalconnectivityoftheparahippocampusandthalamusincrohnsdisease
AT zhouyan alteredmeanapparentpropagatorbasedmicrostructureandthecorrespondingfunctionalconnectivityoftheparahippocampusandthalamusincrohnsdisease