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Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population

We investigated the associations of insulin resistance and β-cell secretion with bone mineral density (BMD) and osteoporosis using data from the National Health and Nutrition Examination Survey. Data on BMD assessed using dual-energy x-ray absorptiometry from 5292 participants were analyzed. Insulin...

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Autores principales: Fu, Yi-Hsiu, Liu, Wei-Ju, Lee, Chia-Lin, Wang, Jun-Sing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530363/
https://www.ncbi.nlm.nih.gov/pubmed/36204101
http://dx.doi.org/10.3389/fendo.2022.971960
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author Fu, Yi-Hsiu
Liu, Wei-Ju
Lee, Chia-Lin
Wang, Jun-Sing
author_facet Fu, Yi-Hsiu
Liu, Wei-Ju
Lee, Chia-Lin
Wang, Jun-Sing
author_sort Fu, Yi-Hsiu
collection PubMed
description We investigated the associations of insulin resistance and β-cell secretion with bone mineral density (BMD) and osteoporosis using data from the National Health and Nutrition Examination Survey. Data on BMD assessed using dual-energy x-ray absorptiometry from 5292 participants were analyzed. Insulin resistance and β-cell secretion were assessed using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and β-cell function (HOMA-β), respectively. We divided the study population into four groups according to HOMA-IR (<2 vs. ≥ 2) and HOMA-β (<100 vs. ≥ 100). BMD and T score at the lumbar spine, hip joint, and femur were used for analyses. Osteoporosis was defined as a T score ≤ -2.5. Logistic regression analyses were conducted to examine the associations of HOMA-IR and HOMA-β with osteoporosis, and the joint effects of HOMA-IR and HOMA-β on osteoporosis. We found a positive association between HOMA-IR and osteoporosis in participants with a HOMA-β ≥ 100 (OR 8.773, 95% CI 2.160-35.637, p=0.002 at the femoral neck). A negative association between HOMA-β and osteoporosis was noted in those with a HOMA-IR <2 (OR 0.183, 95% CI 0.038-0.882, p=0.034 at the femoral neck). Compared with participants who had HOMA-IR <2 and HOMA-β <100, those with HOMA-IR <2 and HOMA-β ≥ 100 had a lower risk of osteoporosis (OR 0.126, 95% CI 0.020-0.805, p=0.032 at the femoral neck). In conclusion, the association between HOMA-β and BMD/osteoporosis changed as HOMA-IR increased. HOMA-β was negatively associated with osteoporosis when HOMA-IR <2. The association was not significant when HOMA-IR ≥ 2.
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spelling pubmed-95303632022-10-05 Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population Fu, Yi-Hsiu Liu, Wei-Ju Lee, Chia-Lin Wang, Jun-Sing Front Endocrinol (Lausanne) Endocrinology We investigated the associations of insulin resistance and β-cell secretion with bone mineral density (BMD) and osteoporosis using data from the National Health and Nutrition Examination Survey. Data on BMD assessed using dual-energy x-ray absorptiometry from 5292 participants were analyzed. Insulin resistance and β-cell secretion were assessed using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and β-cell function (HOMA-β), respectively. We divided the study population into four groups according to HOMA-IR (<2 vs. ≥ 2) and HOMA-β (<100 vs. ≥ 100). BMD and T score at the lumbar spine, hip joint, and femur were used for analyses. Osteoporosis was defined as a T score ≤ -2.5. Logistic regression analyses were conducted to examine the associations of HOMA-IR and HOMA-β with osteoporosis, and the joint effects of HOMA-IR and HOMA-β on osteoporosis. We found a positive association between HOMA-IR and osteoporosis in participants with a HOMA-β ≥ 100 (OR 8.773, 95% CI 2.160-35.637, p=0.002 at the femoral neck). A negative association between HOMA-β and osteoporosis was noted in those with a HOMA-IR <2 (OR 0.183, 95% CI 0.038-0.882, p=0.034 at the femoral neck). Compared with participants who had HOMA-IR <2 and HOMA-β <100, those with HOMA-IR <2 and HOMA-β ≥ 100 had a lower risk of osteoporosis (OR 0.126, 95% CI 0.020-0.805, p=0.032 at the femoral neck). In conclusion, the association between HOMA-β and BMD/osteoporosis changed as HOMA-IR increased. HOMA-β was negatively associated with osteoporosis when HOMA-IR <2. The association was not significant when HOMA-IR ≥ 2. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530363/ /pubmed/36204101 http://dx.doi.org/10.3389/fendo.2022.971960 Text en Copyright © 2022 Fu, Liu, Lee and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Fu, Yi-Hsiu
Liu, Wei-Ju
Lee, Chia-Lin
Wang, Jun-Sing
Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population
title Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population
title_full Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population
title_fullStr Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population
title_full_unstemmed Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population
title_short Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population
title_sort associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530363/
https://www.ncbi.nlm.nih.gov/pubmed/36204101
http://dx.doi.org/10.3389/fendo.2022.971960
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