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Central nervous system tuberculosis in immunocompetent patients: Two case reports with literature review
Central nervous system tuberculosis (CNS) is a rare but extremely dangerous condition that has been reported in 5%-10% of extrapulmonary tuberculosis cases and accounts for approximately 1% of all tuberculosis cases. We present 2 cases of isolated central system tuberculosis in immunocompetent patie...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530405/ https://www.ncbi.nlm.nih.gov/pubmed/36204408 http://dx.doi.org/10.1016/j.radcr.2022.08.085 |
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author | Boularab, Jihad Imrani, Kaoutar Sahli, Hind Billah, Nabil Moatassim Nassar, Itimad |
author_facet | Boularab, Jihad Imrani, Kaoutar Sahli, Hind Billah, Nabil Moatassim Nassar, Itimad |
author_sort | Boularab, Jihad |
collection | PubMed |
description | Central nervous system tuberculosis (CNS) is a rare but extremely dangerous condition that has been reported in 5%-10% of extrapulmonary tuberculosis cases and accounts for approximately 1% of all tuberculosis cases. We present 2 cases of isolated central system tuberculosis in immunocompetent patients: a 57-year-old female and a 22-year-old young man, both of whom had MRI findings consistent with meningitis and tuberculomas and were complicated by cerebral ischemic infarction in the second case. Despite delaying therapy, both patients who had positive TB tests (PCR and QuantiFERON-TB Gold) nevertheless demonstrated clinical improvement. Although central nervous system tuberculosis has a high mortality rate and a high level of neurological morbidity, diagnosing it remains difficult because clinical symptoms and radiological findings can mimic other conditions such as pyogenic abscess, toxoplasmosis, sarcoidosis, and malignancy. |
format | Online Article Text |
id | pubmed-9530405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-95304052022-10-05 Central nervous system tuberculosis in immunocompetent patients: Two case reports with literature review Boularab, Jihad Imrani, Kaoutar Sahli, Hind Billah, Nabil Moatassim Nassar, Itimad Radiol Case Rep Case Report Central nervous system tuberculosis (CNS) is a rare but extremely dangerous condition that has been reported in 5%-10% of extrapulmonary tuberculosis cases and accounts for approximately 1% of all tuberculosis cases. We present 2 cases of isolated central system tuberculosis in immunocompetent patients: a 57-year-old female and a 22-year-old young man, both of whom had MRI findings consistent with meningitis and tuberculomas and were complicated by cerebral ischemic infarction in the second case. Despite delaying therapy, both patients who had positive TB tests (PCR and QuantiFERON-TB Gold) nevertheless demonstrated clinical improvement. Although central nervous system tuberculosis has a high mortality rate and a high level of neurological morbidity, diagnosing it remains difficult because clinical symptoms and radiological findings can mimic other conditions such as pyogenic abscess, toxoplasmosis, sarcoidosis, and malignancy. Elsevier 2022-09-29 /pmc/articles/PMC9530405/ /pubmed/36204408 http://dx.doi.org/10.1016/j.radcr.2022.08.085 Text en © 2022 The Authors. Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Boularab, Jihad Imrani, Kaoutar Sahli, Hind Billah, Nabil Moatassim Nassar, Itimad Central nervous system tuberculosis in immunocompetent patients: Two case reports with literature review |
title | Central nervous system tuberculosis in immunocompetent patients: Two case reports with literature review |
title_full | Central nervous system tuberculosis in immunocompetent patients: Two case reports with literature review |
title_fullStr | Central nervous system tuberculosis in immunocompetent patients: Two case reports with literature review |
title_full_unstemmed | Central nervous system tuberculosis in immunocompetent patients: Two case reports with literature review |
title_short | Central nervous system tuberculosis in immunocompetent patients: Two case reports with literature review |
title_sort | central nervous system tuberculosis in immunocompetent patients: two case reports with literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530405/ https://www.ncbi.nlm.nih.gov/pubmed/36204408 http://dx.doi.org/10.1016/j.radcr.2022.08.085 |
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