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Nail changes in pemphigus and bullous pemphigoid: A single-center study in China

Common autoimmune bullous diseases (AIBDs) include pemphigus and bullous pemphigoid (BP), which are primarily caused by IgG autoantibodies against the structural proteins of desmosomes at the cell–cell junction and hemidesmosomes at the epidermal–dermal junction. Few studies have assessed nail chang...

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Autores principales: Cao, Shan, Cui, Xiaochen, Li, Jianke, Pan, Futang, Yan, Xiaoxiao, Yang, Qing, Chen, Mingfei, Zhou, Shengji, Du, Donghong, Wang, Weiwei, Sun, Yuanhang, Shi, Zhongxiang, Wu, Mei, Yang, Baoqi, Zhang, Furen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530441/
https://www.ncbi.nlm.nih.gov/pubmed/36203762
http://dx.doi.org/10.3389/fmed.2022.933608
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author Cao, Shan
Cui, Xiaochen
Li, Jianke
Pan, Futang
Yan, Xiaoxiao
Yang, Qing
Chen, Mingfei
Zhou, Shengji
Du, Donghong
Wang, Weiwei
Sun, Yuanhang
Shi, Zhongxiang
Wu, Mei
Yang, Baoqi
Zhang, Furen
author_facet Cao, Shan
Cui, Xiaochen
Li, Jianke
Pan, Futang
Yan, Xiaoxiao
Yang, Qing
Chen, Mingfei
Zhou, Shengji
Du, Donghong
Wang, Weiwei
Sun, Yuanhang
Shi, Zhongxiang
Wu, Mei
Yang, Baoqi
Zhang, Furen
author_sort Cao, Shan
collection PubMed
description Common autoimmune bullous diseases (AIBDs) include pemphigus and bullous pemphigoid (BP), which are primarily caused by IgG autoantibodies against the structural proteins of desmosomes at the cell–cell junction and hemidesmosomes at the epidermal–dermal junction. Few studies have assessed nail changes in patients with pemphigus or BP. In the present study, we collected the clinical data of 191 patients with AIBDs (108 patients with pemphigus and 83 patients with BP) and 200 control subjects. Nail changes were observed in 77.0% (147/191), 77.8% (84/108), and 75.9% (63/83) of patients with AIBDs, pemphigus, and BP, respectively, and 14.5% (29/200) of control subjects. Beau's lines and paronychia were the most common nail involvement, observed in 22.5% (43/191) and 22.5% (43/191) of patients with AIBDs, 25.0% (27/108) and 25.9% (28/108) of patients with pemphigus, 19.3% (16/83) and 18.1% (15/83) of patients with BP, respectively. The autoimmune bullous skin disorder intensity score (ABSIS) and the onset time of patients with pemphigus or BP with nail changes were different. Onychomycosis accounted for 21.5% (41/191) of all patients with AIBDs. The ABSIS was correlated with nail involvement in patients with BP (r = 0.46, p < 0.001), and weakly correlated with nail involvement in patients with AIBDs (r = 0.37, p < 0.001), pemphigus (r = 0.29, p = 0.009), and pemphigus vulgaris (PV; r = 0.35, p = 0.008). No correlation was observed between nail involvement and disease antibody titers. In conclusion, nail changes are frequently observed in patients with pemphigus and BP. The type and onset time of nail changes may indicate the severity of pemphigus and BP, which warrants the attention of dermatologists.
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spelling pubmed-95304412022-10-05 Nail changes in pemphigus and bullous pemphigoid: A single-center study in China Cao, Shan Cui, Xiaochen Li, Jianke Pan, Futang Yan, Xiaoxiao Yang, Qing Chen, Mingfei Zhou, Shengji Du, Donghong Wang, Weiwei Sun, Yuanhang Shi, Zhongxiang Wu, Mei Yang, Baoqi Zhang, Furen Front Med (Lausanne) Medicine Common autoimmune bullous diseases (AIBDs) include pemphigus and bullous pemphigoid (BP), which are primarily caused by IgG autoantibodies against the structural proteins of desmosomes at the cell–cell junction and hemidesmosomes at the epidermal–dermal junction. Few studies have assessed nail changes in patients with pemphigus or BP. In the present study, we collected the clinical data of 191 patients with AIBDs (108 patients with pemphigus and 83 patients with BP) and 200 control subjects. Nail changes were observed in 77.0% (147/191), 77.8% (84/108), and 75.9% (63/83) of patients with AIBDs, pemphigus, and BP, respectively, and 14.5% (29/200) of control subjects. Beau's lines and paronychia were the most common nail involvement, observed in 22.5% (43/191) and 22.5% (43/191) of patients with AIBDs, 25.0% (27/108) and 25.9% (28/108) of patients with pemphigus, 19.3% (16/83) and 18.1% (15/83) of patients with BP, respectively. The autoimmune bullous skin disorder intensity score (ABSIS) and the onset time of patients with pemphigus or BP with nail changes were different. Onychomycosis accounted for 21.5% (41/191) of all patients with AIBDs. The ABSIS was correlated with nail involvement in patients with BP (r = 0.46, p < 0.001), and weakly correlated with nail involvement in patients with AIBDs (r = 0.37, p < 0.001), pemphigus (r = 0.29, p = 0.009), and pemphigus vulgaris (PV; r = 0.35, p = 0.008). No correlation was observed between nail involvement and disease antibody titers. In conclusion, nail changes are frequently observed in patients with pemphigus and BP. The type and onset time of nail changes may indicate the severity of pemphigus and BP, which warrants the attention of dermatologists. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530441/ /pubmed/36203762 http://dx.doi.org/10.3389/fmed.2022.933608 Text en Copyright © 2022 Cao, Cui, Li, Pan, Yan, Yang, Chen, Zhou, Du, Wang, Sun, Shi, Wu, Yang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Cao, Shan
Cui, Xiaochen
Li, Jianke
Pan, Futang
Yan, Xiaoxiao
Yang, Qing
Chen, Mingfei
Zhou, Shengji
Du, Donghong
Wang, Weiwei
Sun, Yuanhang
Shi, Zhongxiang
Wu, Mei
Yang, Baoqi
Zhang, Furen
Nail changes in pemphigus and bullous pemphigoid: A single-center study in China
title Nail changes in pemphigus and bullous pemphigoid: A single-center study in China
title_full Nail changes in pemphigus and bullous pemphigoid: A single-center study in China
title_fullStr Nail changes in pemphigus and bullous pemphigoid: A single-center study in China
title_full_unstemmed Nail changes in pemphigus and bullous pemphigoid: A single-center study in China
title_short Nail changes in pemphigus and bullous pemphigoid: A single-center study in China
title_sort nail changes in pemphigus and bullous pemphigoid: a single-center study in china
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530441/
https://www.ncbi.nlm.nih.gov/pubmed/36203762
http://dx.doi.org/10.3389/fmed.2022.933608
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