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Association between blood viscosity and early neurological deterioration in lacunar infarction

BACKGROUND: Understanding the factors related to early neurologic deterioration (END) is crucial in the management of patients with lacunar infarction. Blood viscosity is a significant factor for microvascular perfusion. We investigated the association between blood viscosity and occurrence of END i...

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Autores principales: Lee, Hyungwoo, Heo, JoonNyung, Lee, Il Hyung, Kim, Young Dae, Nam, Hyo Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530465/
https://www.ncbi.nlm.nih.gov/pubmed/36203995
http://dx.doi.org/10.3389/fneur.2022.979073
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author Lee, Hyungwoo
Heo, JoonNyung
Lee, Il Hyung
Kim, Young Dae
Nam, Hyo Suk
author_facet Lee, Hyungwoo
Heo, JoonNyung
Lee, Il Hyung
Kim, Young Dae
Nam, Hyo Suk
author_sort Lee, Hyungwoo
collection PubMed
description BACKGROUND: Understanding the factors related to early neurologic deterioration (END) is crucial in the management of patients with lacunar infarction. Blood viscosity is a significant factor for microvascular perfusion. We investigated the association between blood viscosity and occurrence of END in lacunar infarction. METHODS: We included consecutive patients admitted for lacunar infarction within 72 h from symptoms onset. END was defined as an increase in the National Institute of Health Stroke Scale (NIHSS) score ≥2 within 24 h of admission. Viscosity was measured within 24 h of hospitalization with a scanning capillary tube viscometer. Viscosity measured at a shear rate of 300 s(−1) was defined as systolic blood viscosity (SBV), whereas that measured at a shear rate of 5 s(−1) as diastolic blood viscosity (DBV). RESULTS: Of the 178 patients included (median age, 65.5; interquartile range [IQR], 56.0, 76.0], END occurred in 33 (18.5%). DBV was significantly higher in patients with END than those without END (13.3 mPa·s [IQR 11.8, 16.0] vs. 12.3 mPa·s [IQR11.0, 13.5]; P = 0.023). In the multivariate analysis, DBV was independently associated with the occurrence of END (odds ratio 1.17; 95% confidence interval 1.01–1.36; P = 0.043). Subgroup analysis showed no heterogeneity in the effect of viscosity on the occurrence of END. CONCLUSIONS: Blood viscosity at a low shear rate (DBV) was associated with the occurrence of END in patients with lacunar infarction. Blood rheology may be important in pathophysiology of END in patients with lacunar infarction.
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spelling pubmed-95304652022-10-05 Association between blood viscosity and early neurological deterioration in lacunar infarction Lee, Hyungwoo Heo, JoonNyung Lee, Il Hyung Kim, Young Dae Nam, Hyo Suk Front Neurol Neurology BACKGROUND: Understanding the factors related to early neurologic deterioration (END) is crucial in the management of patients with lacunar infarction. Blood viscosity is a significant factor for microvascular perfusion. We investigated the association between blood viscosity and occurrence of END in lacunar infarction. METHODS: We included consecutive patients admitted for lacunar infarction within 72 h from symptoms onset. END was defined as an increase in the National Institute of Health Stroke Scale (NIHSS) score ≥2 within 24 h of admission. Viscosity was measured within 24 h of hospitalization with a scanning capillary tube viscometer. Viscosity measured at a shear rate of 300 s(−1) was defined as systolic blood viscosity (SBV), whereas that measured at a shear rate of 5 s(−1) as diastolic blood viscosity (DBV). RESULTS: Of the 178 patients included (median age, 65.5; interquartile range [IQR], 56.0, 76.0], END occurred in 33 (18.5%). DBV was significantly higher in patients with END than those without END (13.3 mPa·s [IQR 11.8, 16.0] vs. 12.3 mPa·s [IQR11.0, 13.5]; P = 0.023). In the multivariate analysis, DBV was independently associated with the occurrence of END (odds ratio 1.17; 95% confidence interval 1.01–1.36; P = 0.043). Subgroup analysis showed no heterogeneity in the effect of viscosity on the occurrence of END. CONCLUSIONS: Blood viscosity at a low shear rate (DBV) was associated with the occurrence of END in patients with lacunar infarction. Blood rheology may be important in pathophysiology of END in patients with lacunar infarction. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530465/ /pubmed/36203995 http://dx.doi.org/10.3389/fneur.2022.979073 Text en Copyright © 2022 Lee, Heo, Lee, Kim and Nam. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Lee, Hyungwoo
Heo, JoonNyung
Lee, Il Hyung
Kim, Young Dae
Nam, Hyo Suk
Association between blood viscosity and early neurological deterioration in lacunar infarction
title Association between blood viscosity and early neurological deterioration in lacunar infarction
title_full Association between blood viscosity and early neurological deterioration in lacunar infarction
title_fullStr Association between blood viscosity and early neurological deterioration in lacunar infarction
title_full_unstemmed Association between blood viscosity and early neurological deterioration in lacunar infarction
title_short Association between blood viscosity and early neurological deterioration in lacunar infarction
title_sort association between blood viscosity and early neurological deterioration in lacunar infarction
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530465/
https://www.ncbi.nlm.nih.gov/pubmed/36203995
http://dx.doi.org/10.3389/fneur.2022.979073
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