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Relationship between bronchopulmonary dysplasia phenotypes with high-resolution computed tomography score in early preterm infants

OBJECTIVE: To assess the relationship between high-resolution computed tomography (HRCT) abnormalities and clinical phenotypes of bronchopulmonary dysplasia (BPD). METHODS: A retrospective, single-center study was carried out at the Children’s Hospital of Fudan University between 2013 and 2020. Pret...

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Autores principales: Yao, Qiong, Shen, Quan-li, Huang, Guo-ying, Hu, Xi-hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530466/
https://www.ncbi.nlm.nih.gov/pubmed/36204662
http://dx.doi.org/10.3389/fped.2022.935733
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author Yao, Qiong
Shen, Quan-li
Huang, Guo-ying
Hu, Xi-hong
author_facet Yao, Qiong
Shen, Quan-li
Huang, Guo-ying
Hu, Xi-hong
author_sort Yao, Qiong
collection PubMed
description OBJECTIVE: To assess the relationship between high-resolution computed tomography (HRCT) abnormalities and clinical phenotypes of bronchopulmonary dysplasia (BPD). METHODS: A retrospective, single-center study was carried out at the Children’s Hospital of Fudan University between 2013 and 2020. Preterm infants born at ≤ 32 weeks’ gestation who were diagnosed with BPD and had HRCT between 40 and 50 weeks postmenstrual age (PMA)were included in the study. HRCT images from six pulmonary lobes were scored based on seven types of pulmonary lesions from two categories: hyperaeration lesions and parenchymal lesions. The hyperaeration score (HS) included scores of decreased attenuation, mosaic attenuation, and bulla/bleb, while the parenchymal score (PS) included those of linear lesion, consolidation, bronchial wall thickening, and bronchiectasis. All seven scores were summed up to create the total score (TS). One-way ANOVA testing or Kruskal-Wallis testing was adopted for the comparison of HRCT scores with BPD severity and clinical phenotypes. The correlation between HRCT scores and clinical phenotypes was evaluated by Spearman’s correlation analysis. RESULTS: A total of 81 cases were included in the study. Cases with more severe BPD had a higher TS (p = 0.01), HS (p = 0.02), PS (p = 0.02), mosaic attenuation score (p = 0.03), bulla/Bleb score (p = 0.03), and linear density score (p = 0.01). TS (r = 0.28), PS (r = 0.35), linear density (r = 0.34), and consolidation (r = 0.24) were correlated with pulmonary hypertension (PH). However, no HRCT score was significantly different between the patients with or without tracheobronchomalacia (TBM). BPD patients with a combination of lung parenchymal disease, PH, and TBM had the highest TS and HS. CONCLUSION: HRCT scores correlated with BPD severity and PH in our study. HS might be a useful tool in the assessment of BPD severity while linear densities and consolidation might be helpful in predicting PH.
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spelling pubmed-95304662022-10-05 Relationship between bronchopulmonary dysplasia phenotypes with high-resolution computed tomography score in early preterm infants Yao, Qiong Shen, Quan-li Huang, Guo-ying Hu, Xi-hong Front Pediatr Pediatrics OBJECTIVE: To assess the relationship between high-resolution computed tomography (HRCT) abnormalities and clinical phenotypes of bronchopulmonary dysplasia (BPD). METHODS: A retrospective, single-center study was carried out at the Children’s Hospital of Fudan University between 2013 and 2020. Preterm infants born at ≤ 32 weeks’ gestation who were diagnosed with BPD and had HRCT between 40 and 50 weeks postmenstrual age (PMA)were included in the study. HRCT images from six pulmonary lobes were scored based on seven types of pulmonary lesions from two categories: hyperaeration lesions and parenchymal lesions. The hyperaeration score (HS) included scores of decreased attenuation, mosaic attenuation, and bulla/bleb, while the parenchymal score (PS) included those of linear lesion, consolidation, bronchial wall thickening, and bronchiectasis. All seven scores were summed up to create the total score (TS). One-way ANOVA testing or Kruskal-Wallis testing was adopted for the comparison of HRCT scores with BPD severity and clinical phenotypes. The correlation between HRCT scores and clinical phenotypes was evaluated by Spearman’s correlation analysis. RESULTS: A total of 81 cases were included in the study. Cases with more severe BPD had a higher TS (p = 0.01), HS (p = 0.02), PS (p = 0.02), mosaic attenuation score (p = 0.03), bulla/Bleb score (p = 0.03), and linear density score (p = 0.01). TS (r = 0.28), PS (r = 0.35), linear density (r = 0.34), and consolidation (r = 0.24) were correlated with pulmonary hypertension (PH). However, no HRCT score was significantly different between the patients with or without tracheobronchomalacia (TBM). BPD patients with a combination of lung parenchymal disease, PH, and TBM had the highest TS and HS. CONCLUSION: HRCT scores correlated with BPD severity and PH in our study. HS might be a useful tool in the assessment of BPD severity while linear densities and consolidation might be helpful in predicting PH. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530466/ /pubmed/36204662 http://dx.doi.org/10.3389/fped.2022.935733 Text en Copyright © 2022 Yao, Shen, Huang and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Yao, Qiong
Shen, Quan-li
Huang, Guo-ying
Hu, Xi-hong
Relationship between bronchopulmonary dysplasia phenotypes with high-resolution computed tomography score in early preterm infants
title Relationship between bronchopulmonary dysplasia phenotypes with high-resolution computed tomography score in early preterm infants
title_full Relationship between bronchopulmonary dysplasia phenotypes with high-resolution computed tomography score in early preterm infants
title_fullStr Relationship between bronchopulmonary dysplasia phenotypes with high-resolution computed tomography score in early preterm infants
title_full_unstemmed Relationship between bronchopulmonary dysplasia phenotypes with high-resolution computed tomography score in early preterm infants
title_short Relationship between bronchopulmonary dysplasia phenotypes with high-resolution computed tomography score in early preterm infants
title_sort relationship between bronchopulmonary dysplasia phenotypes with high-resolution computed tomography score in early preterm infants
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530466/
https://www.ncbi.nlm.nih.gov/pubmed/36204662
http://dx.doi.org/10.3389/fped.2022.935733
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