Cardiac MRF using rosette trajectories for simultaneous myocardial T(1), T(2), and proton density fat fraction mapping

The goal of this work is to extend prior work on cardiac MR Fingerprinting (cMRF) using rosette k-space trajectories to enable simultaneous T(1), T(2), and proton density fat fraction (PDFF) mapping in the heart. A rosette trajectory designed for water-fat separation at 1.5T was used in a 2D ECG-triggered 15-heartbeat cMRF sequence. Water and fat specific T(1) and T(2) maps were generated from the cMRF data. A PDFF map was also retrieved using Hierarchical IDEAL by segmenting the rosette cMRF data into multiple echoes. The accuracy of rosette cMRF in T(1), T(2), and PDFF quantification was validated in the ISMRM/NIST phantom and an in-house built fat fraction phantom, respectively. The proposed method was also applied for myocardial tissue mapping of healthy subjects and cardiac patients at 1.5T. T(1), T(2), and PDFF values measured using rosette cMRF in the ISMRM/NIST phantom and the fat fraction phantom agreed well with the reference values. In 16 healthy subjects, rosette cMRF yielded T(1) values which were 80~90 ms higher than spiral cMRF and MOLLI. T(2) values obtained using rosette cMRF were ~3 ms higher than spiral cMRF and ~5 ms lower than conventional T(2)-prep bSSFP method. Rosette cMRF was also able to detect abnormal T(1) and T(2) values in cardiomyopathy patients and may provide more accurate maps due to effective fat suppression. In conclusion, this study shows that rosette cMRF has the potential for efficient cardiac tissue characterization through simultaneous quantification of myocardial T(1), T(2), and PDFF.