Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements

BACKGROUND: Tobacco exposure causes 8 of 10 lung cancers, and identifying additional risk factors is challenging due to confounding introduced by smoking in traditional observational studies. MATERIALS AND METHODS: We used Mendelian randomization (MR) to screen 207 metabolites for their role in lung...

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Detalles Bibliográficos
Autores principales: Smith-Byrne, Karl, Cerani, Agustin, Guida, Florence, Zhou, Sirui, Agudo, Antonio, Aleksandrova, Krasimira, Barricarte, Aurelio, Barranco, Miguel Rodríguez, Bochers, Christoph H., Gram, Inger Torhild, Han, Jun, Amos, Christopher I., Hung, Rayjean J., Grankvist, Kjell, Nøst, Therese Haugdhal, Imaz, Liher, Chirlaque-López, María Dolores, Johansson, Mikael, Kaaks, Rudolf, Kühn, Tilman, Martin, Richard M., McKay, James D., Pala, Valeria, Robbins, Hilary A., Sandanger, Torkjel M., Schibli, David, Schulze, Matthias B., Travis, Ruth C., Vineis, Paolo, Weiderpass, Elisabete, Brennan, Paul, Johansson, Mattias, Richards, J. Brent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530646/
https://www.ncbi.nlm.nih.gov/pubmed/35839461
http://dx.doi.org/10.1158/1055-9965.EPI-21-1033

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