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Spinal orexin A attenuates opioid-induced mechanical hypersensitivity in the rat

BACKGROUND: Repeated administration of opioid analgesics for pain treatment can produce paradoxical hyperalgesia via peripheral and/or central mechanisms. Thus, this study investigated whether spinally (centrally) administered orexin A attenuates opioid-induced hyperalgesia (OIH). METHODS: [D-Ala(2)...

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Detalles Bibliográficos
Autores principales:	Youn, Dong-ho, Jun, Jiyeon, Kim, Tae Wan, Park, Kibeom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Pain Society 2022
Materias:	Experimental Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530684/ https://www.ncbi.nlm.nih.gov/pubmed/36175342 http://dx.doi.org/10.3344/kjp.2022.35.4.433

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