Cargando…

Implantation metastasis from sigmoid colon cancer to rectal anastomosis proved by whole exome sequencing and lineage inference for cancer heterogeneity and evolution analysis: Case report and literature review

It was estimated that 70% of patients with colorectal cancer were found to have viable exfoliated malignant cells in adjacent intestinal lumen. Exfoliated malignant cells had been reported to implant on raw surfaces, such as polypectomy site, anal fissure, anal fistula, hemorrhoidectomy wound, and a...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Guan Yu, Gao, Xian Hua, Xia, Li Jian, Sun, De Bin, Liu, Tao, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530747/
https://www.ncbi.nlm.nih.gov/pubmed/36203423
http://dx.doi.org/10.3389/fonc.2022.930715
_version_ 1784801754190184448
author Yu, Guan Yu
Gao, Xian Hua
Xia, Li Jian
Sun, De Bin
Liu, Tao
Zhang, Wei
author_facet Yu, Guan Yu
Gao, Xian Hua
Xia, Li Jian
Sun, De Bin
Liu, Tao
Zhang, Wei
author_sort Yu, Guan Yu
collection PubMed
description It was estimated that 70% of patients with colorectal cancer were found to have viable exfoliated malignant cells in adjacent intestinal lumen. Exfoliated malignant cells had been reported to implant on raw surfaces, such as polypectomy site, anal fissure, anal fistula, hemorrhoidectomy wound, and anastomotic suture line. Tumors at anastomosis could be classified into four groups: local recurrence, local manifestation of widespread metastasis, metachronous carcinogenesis, and implantation metastasis. However, all of the previous studies only reported the phenomena of implantation metastasis at anastomosis. No study had proved the origin of anastomotic metastasis by genomic analysis. In this study, a 43-year-old woman presented with persistent hematochezia was diagnosed as having severe mixed hemorrhoids. She was treated by procedure for prolapse and hemorrhoids (PPH), without receiving preoperative colonoscopy. Two months later, she was found to have sigmoid colon cancer by colonoscopy due to continuous hematochezia and received radical sigmoidectomy. Postoperative histological examination confirmed the lesion to be a moderately differentiated adenocarcinoma (pT3N1M0). Six months later, she presented with hematochezia again and colonoscopy revealed two tumors at the rectal anastomosis of PPH. Both tumors were confirmed to be moderately differentiated adenocarcinoma without lymph node and distant metastasis and were finally removed by transanal endoscopic microsurgery (TEM). Pathological examination, whole exome sequencing (WES), and Lineage Inference for Cancer Heterogeneity and Evolution (LICHeE) analysis demonstrated that the two tumors at the rectal anastomosis were probably implantation metastases arising from the previous sigmoid colon cancer. This is the first study to prove implantation metastasis from colon cancer to a distal anastomosis by WES and LICHeE analysis. Therefore, it is recommended to rule out colorectal cancer in proximal large bowel before performing surgery with a rectal anastomosis, such as PPH and anterior resection. For patients with a suspected implanted tumor, WES and LICHeE could be used to differentiate implantation metastasis from metachronous carcinogenesis.
format Online
Article
Text
id pubmed-9530747
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95307472022-10-05 Implantation metastasis from sigmoid colon cancer to rectal anastomosis proved by whole exome sequencing and lineage inference for cancer heterogeneity and evolution analysis: Case report and literature review Yu, Guan Yu Gao, Xian Hua Xia, Li Jian Sun, De Bin Liu, Tao Zhang, Wei Front Oncol Oncology It was estimated that 70% of patients with colorectal cancer were found to have viable exfoliated malignant cells in adjacent intestinal lumen. Exfoliated malignant cells had been reported to implant on raw surfaces, such as polypectomy site, anal fissure, anal fistula, hemorrhoidectomy wound, and anastomotic suture line. Tumors at anastomosis could be classified into four groups: local recurrence, local manifestation of widespread metastasis, metachronous carcinogenesis, and implantation metastasis. However, all of the previous studies only reported the phenomena of implantation metastasis at anastomosis. No study had proved the origin of anastomotic metastasis by genomic analysis. In this study, a 43-year-old woman presented with persistent hematochezia was diagnosed as having severe mixed hemorrhoids. She was treated by procedure for prolapse and hemorrhoids (PPH), without receiving preoperative colonoscopy. Two months later, she was found to have sigmoid colon cancer by colonoscopy due to continuous hematochezia and received radical sigmoidectomy. Postoperative histological examination confirmed the lesion to be a moderately differentiated adenocarcinoma (pT3N1M0). Six months later, she presented with hematochezia again and colonoscopy revealed two tumors at the rectal anastomosis of PPH. Both tumors were confirmed to be moderately differentiated adenocarcinoma without lymph node and distant metastasis and were finally removed by transanal endoscopic microsurgery (TEM). Pathological examination, whole exome sequencing (WES), and Lineage Inference for Cancer Heterogeneity and Evolution (LICHeE) analysis demonstrated that the two tumors at the rectal anastomosis were probably implantation metastases arising from the previous sigmoid colon cancer. This is the first study to prove implantation metastasis from colon cancer to a distal anastomosis by WES and LICHeE analysis. Therefore, it is recommended to rule out colorectal cancer in proximal large bowel before performing surgery with a rectal anastomosis, such as PPH and anterior resection. For patients with a suspected implanted tumor, WES and LICHeE could be used to differentiate implantation metastasis from metachronous carcinogenesis. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530747/ /pubmed/36203423 http://dx.doi.org/10.3389/fonc.2022.930715 Text en Copyright © 2022 Yu, Gao, Xia, Sun, Liu and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yu, Guan Yu
Gao, Xian Hua
Xia, Li Jian
Sun, De Bin
Liu, Tao
Zhang, Wei
Implantation metastasis from sigmoid colon cancer to rectal anastomosis proved by whole exome sequencing and lineage inference for cancer heterogeneity and evolution analysis: Case report and literature review
title Implantation metastasis from sigmoid colon cancer to rectal anastomosis proved by whole exome sequencing and lineage inference for cancer heterogeneity and evolution analysis: Case report and literature review
title_full Implantation metastasis from sigmoid colon cancer to rectal anastomosis proved by whole exome sequencing and lineage inference for cancer heterogeneity and evolution analysis: Case report and literature review
title_fullStr Implantation metastasis from sigmoid colon cancer to rectal anastomosis proved by whole exome sequencing and lineage inference for cancer heterogeneity and evolution analysis: Case report and literature review
title_full_unstemmed Implantation metastasis from sigmoid colon cancer to rectal anastomosis proved by whole exome sequencing and lineage inference for cancer heterogeneity and evolution analysis: Case report and literature review
title_short Implantation metastasis from sigmoid colon cancer to rectal anastomosis proved by whole exome sequencing and lineage inference for cancer heterogeneity and evolution analysis: Case report and literature review
title_sort implantation metastasis from sigmoid colon cancer to rectal anastomosis proved by whole exome sequencing and lineage inference for cancer heterogeneity and evolution analysis: case report and literature review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530747/
https://www.ncbi.nlm.nih.gov/pubmed/36203423
http://dx.doi.org/10.3389/fonc.2022.930715
work_keys_str_mv AT yuguanyu implantationmetastasisfromsigmoidcoloncancertorectalanastomosisprovedbywholeexomesequencingandlineageinferenceforcancerheterogeneityandevolutionanalysiscasereportandliteraturereview
AT gaoxianhua implantationmetastasisfromsigmoidcoloncancertorectalanastomosisprovedbywholeexomesequencingandlineageinferenceforcancerheterogeneityandevolutionanalysiscasereportandliteraturereview
AT xialijian implantationmetastasisfromsigmoidcoloncancertorectalanastomosisprovedbywholeexomesequencingandlineageinferenceforcancerheterogeneityandevolutionanalysiscasereportandliteraturereview
AT sundebin implantationmetastasisfromsigmoidcoloncancertorectalanastomosisprovedbywholeexomesequencingandlineageinferenceforcancerheterogeneityandevolutionanalysiscasereportandliteraturereview
AT liutao implantationmetastasisfromsigmoidcoloncancertorectalanastomosisprovedbywholeexomesequencingandlineageinferenceforcancerheterogeneityandevolutionanalysiscasereportandliteraturereview
AT zhangwei implantationmetastasisfromsigmoidcoloncancertorectalanastomosisprovedbywholeexomesequencingandlineageinferenceforcancerheterogeneityandevolutionanalysiscasereportandliteraturereview