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DNA methyltransferase DNMT3A forms interaction networks with the CpG site and flanking sequence elements for efficient methylation

Specific DNA methylation at CpG and non-CpG sites is essential for chromatin regulation. The DNA methyltransferase DNMT3A interacts with target sites surrounded by variable DNA sequences with its TRD and RD loops, but the functional necessity of these interactions is unclear. We investigated CpG and...

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Detalles Bibliográficos
Autores principales:	Dukatz, Michael, Dittrich, Marianna, Stahl, Elias, Adam, Sabrina, de Mendoza, Alex, Bashtrykov, Pavel, Jeltsch, Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530848/ https://www.ncbi.nlm.nih.gov/pubmed/36067881 http://dx.doi.org/10.1016/j.jbc.2022.102462

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