Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

Interaction with microenvironmental factors is crucial for the regulation of hematopoietic stem cell (HSC) function. Stroma derived factor (SDF)-1α supports HSCs in the quiescent state and is central to the homing of transplanted HSCs. Here, we show that integrin signaling regulates Sdf-1α expressio...

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Detalles Bibliográficos
Autores principales: Roy, Irene Mariam, Anu, P.V., Zaunz, Samantha, Reddi, Srinu, Giri, Aravind M., Sankar, Rithika Saroj, Schouteden, Sarah, Huelsken, Joerg, Verfaillie, Catherine M., Khurana, Satish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530850/
https://www.ncbi.nlm.nih.gov/pubmed/36204266
http://dx.doi.org/10.1016/j.isci.2022.105171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530850/
https://www.ncbi.nlm.nih.gov/pubmed/36204266
http://dx.doi.org/10.1016/j.isci.2022.105171

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