Tumor microenvironmental 15‐PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer

The arachidonic acid cascade is a major inflammatory pathway that produces prostaglandin E(2) (PGE2). Although inhibition of 15‐hydroxyprostaglandin dehydrogenase (15‐PGDH) is reported to lead to PGE2 accumulation, the role of 15‐PGDH expression in the tumor microenvironment remains unclear. We util...

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Detalles Bibliográficos
Autores principales: Bu, Luke, Yonemura, Atsuko, Yasuda‐Yoshihara, Noriko, Uchihara, Tomoyuki, Ismagulov, Galym, Takasugi, Sanae, Yasuda, Tadahito, Okamoto, Yuya, Kitamura, Fumimasa, Akiyama, Takahiko, Arima, Kota, Itoyama, Rumi, Zhang, Jun, Fu, Lingfeng, Hu, Xichen, Wei, Feng, Arima, Yuichiro, Moroishi, Toshiro, Nishiyama, Koichi, Sheng, Guojun, Mukunoki, Toshifumi, Otani, Jun, Baba, Hideo, Ishimoto, Takatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530869/
https://www.ncbi.nlm.nih.gov/pubmed/35848891
http://dx.doi.org/10.1111/cas.15495

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