Drug repositioning of tranilast to sensitize a cancer therapy by targeting cancer‐associated fibroblast

Cancer‐associated fibroblasts (CAFs) are a major component of the tumor microenvironment that mediate resistance of cancer cells to anticancer drugs. Tranilast is an antiallergic drug that suppresses the release of cytokines from various inflammatory cells. In this study, we investigated the inhibit...

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Detalles Bibliográficos
Autores principales: Ochi, Kosuke, Suzawa, Ken, Thu, Yin Min, Takatsu, Fumiaki, Tsudaka, Shimpei, Zhu, Yidan, Nakata, Kentaro, Takeda, Tatsuaki, Shien, Kazuhiko, Yamamoto, Hiromasa, Okazaki, Mikio, Sugimoto, Seiichiro, Shien, Tadahiko, Okamoto, Yoshiharu, Tomida, Shuta, Toyooka, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530873/
https://www.ncbi.nlm.nih.gov/pubmed/35871750
http://dx.doi.org/10.1111/cas.15502

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