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Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report
Pseudorabies virus (PRV) is a common pig infectious disease. There have been few reports of PRV infection in humans. The patient in this article had acute onset, which was manifested by fever, epilepsy, disturbance of consciousness, and other symptoms. The disease progressed rapidly and worsened in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530976/ https://www.ncbi.nlm.nih.gov/pubmed/36203976 http://dx.doi.org/10.3389/fneur.2022.950931 |
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author | Huang, Hui Wang, Na Ai, Zhi-Bing Chen, Jun Huang, Wei Bao, Yi |
author_facet | Huang, Hui Wang, Na Ai, Zhi-Bing Chen, Jun Huang, Wei Bao, Yi |
author_sort | Huang, Hui |
collection | PubMed |
description | Pseudorabies virus (PRV) is a common pig infectious disease. There have been few reports of PRV infection in humans. The patient in this article had acute onset, which was manifested by fever, epilepsy, disturbance of consciousness, and other symptoms. The disease progressed rapidly and worsened in a short time so the ventilator had to be used to assist breathing. In the later stage of treatment, serious visual impairment also occurred. Pseudorabies virus was found in cerebrospinal fluid by second-generation gene sequencing (NGS). This indicates that the pseudorabies virus can spread across species, leading to human encephalitis and severe visual impairment. Therefore, attention should be paid to this disease, active prevention, and early detection are helpful to improve the treatment effect. |
format | Online Article Text |
id | pubmed-9530976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95309762022-10-05 Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report Huang, Hui Wang, Na Ai, Zhi-Bing Chen, Jun Huang, Wei Bao, Yi Front Neurol Neurology Pseudorabies virus (PRV) is a common pig infectious disease. There have been few reports of PRV infection in humans. The patient in this article had acute onset, which was manifested by fever, epilepsy, disturbance of consciousness, and other symptoms. The disease progressed rapidly and worsened in a short time so the ventilator had to be used to assist breathing. In the later stage of treatment, serious visual impairment also occurred. Pseudorabies virus was found in cerebrospinal fluid by second-generation gene sequencing (NGS). This indicates that the pseudorabies virus can spread across species, leading to human encephalitis and severe visual impairment. Therefore, attention should be paid to this disease, active prevention, and early detection are helpful to improve the treatment effect. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530976/ /pubmed/36203976 http://dx.doi.org/10.3389/fneur.2022.950931 Text en Copyright © 2022 Huang, Wang, Ai, Chen, Huang and Bao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Huang, Hui Wang, Na Ai, Zhi-Bing Chen, Jun Huang, Wei Bao, Yi Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report |
title | Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report |
title_full | Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report |
title_fullStr | Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report |
title_full_unstemmed | Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report |
title_short | Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report |
title_sort | cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: a case report |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530976/ https://www.ncbi.nlm.nih.gov/pubmed/36203976 http://dx.doi.org/10.3389/fneur.2022.950931 |
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