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Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report

Pseudorabies virus (PRV) is a common pig infectious disease. There have been few reports of PRV infection in humans. The patient in this article had acute onset, which was manifested by fever, epilepsy, disturbance of consciousness, and other symptoms. The disease progressed rapidly and worsened in...

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Autores principales: Huang, Hui, Wang, Na, Ai, Zhi-Bing, Chen, Jun, Huang, Wei, Bao, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530976/
https://www.ncbi.nlm.nih.gov/pubmed/36203976
http://dx.doi.org/10.3389/fneur.2022.950931
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author Huang, Hui
Wang, Na
Ai, Zhi-Bing
Chen, Jun
Huang, Wei
Bao, Yi
author_facet Huang, Hui
Wang, Na
Ai, Zhi-Bing
Chen, Jun
Huang, Wei
Bao, Yi
author_sort Huang, Hui
collection PubMed
description Pseudorabies virus (PRV) is a common pig infectious disease. There have been few reports of PRV infection in humans. The patient in this article had acute onset, which was manifested by fever, epilepsy, disturbance of consciousness, and other symptoms. The disease progressed rapidly and worsened in a short time so the ventilator had to be used to assist breathing. In the later stage of treatment, serious visual impairment also occurred. Pseudorabies virus was found in cerebrospinal fluid by second-generation gene sequencing (NGS). This indicates that the pseudorabies virus can spread across species, leading to human encephalitis and severe visual impairment. Therefore, attention should be paid to this disease, active prevention, and early detection are helpful to improve the treatment effect.
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spelling pubmed-95309762022-10-05 Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report Huang, Hui Wang, Na Ai, Zhi-Bing Chen, Jun Huang, Wei Bao, Yi Front Neurol Neurology Pseudorabies virus (PRV) is a common pig infectious disease. There have been few reports of PRV infection in humans. The patient in this article had acute onset, which was manifested by fever, epilepsy, disturbance of consciousness, and other symptoms. The disease progressed rapidly and worsened in a short time so the ventilator had to be used to assist breathing. In the later stage of treatment, serious visual impairment also occurred. Pseudorabies virus was found in cerebrospinal fluid by second-generation gene sequencing (NGS). This indicates that the pseudorabies virus can spread across species, leading to human encephalitis and severe visual impairment. Therefore, attention should be paid to this disease, active prevention, and early detection are helpful to improve the treatment effect. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530976/ /pubmed/36203976 http://dx.doi.org/10.3389/fneur.2022.950931 Text en Copyright © 2022 Huang, Wang, Ai, Chen, Huang and Bao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Huang, Hui
Wang, Na
Ai, Zhi-Bing
Chen, Jun
Huang, Wei
Bao, Yi
Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report
title Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report
title_full Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report
title_fullStr Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report
title_full_unstemmed Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report
title_short Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report
title_sort cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: a case report
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530976/
https://www.ncbi.nlm.nih.gov/pubmed/36203976
http://dx.doi.org/10.3389/fneur.2022.950931
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