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Differential glutamine metabolism in the tumor microenvironment – studies in diversity and heterogeneity: A mini-review

Increased glutamine metabolism is a hallmark of many cancer types. In recent years, our understanding of the distinct and diverse metabolic pathways through which glutamine can be utilized has grown more refined. Additionally, the different metabolic requirements of the diverse array of cell types w...

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Detalles Bibliográficos
Autores principales: Claiborne, Michael D., Leone, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531032/
https://www.ncbi.nlm.nih.gov/pubmed/36203456
http://dx.doi.org/10.3389/fonc.2022.1011191
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author Claiborne, Michael D.
Leone, Robert
author_facet Claiborne, Michael D.
Leone, Robert
author_sort Claiborne, Michael D.
collection PubMed
description Increased glutamine metabolism is a hallmark of many cancer types. In recent years, our understanding of the distinct and diverse metabolic pathways through which glutamine can be utilized has grown more refined. Additionally, the different metabolic requirements of the diverse array of cell types within the tumor microenvironment complicate the strategy of targeting any particular glutamine pathway as cancer therapy. In this Mini-Review, we discuss recent advances in further clarifying the cellular fate of glutamine through different metabolic pathways. We further discuss potential promising strategies which exploit the different requirements of cells in the tumor microenvironment as it pertains to glutamine metabolism in an attempt to suppress cancer growth and enhance anti-tumor immune responses.
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spelling pubmed-95310322022-10-05 Differential glutamine metabolism in the tumor microenvironment – studies in diversity and heterogeneity: A mini-review Claiborne, Michael D. Leone, Robert Front Oncol Oncology Increased glutamine metabolism is a hallmark of many cancer types. In recent years, our understanding of the distinct and diverse metabolic pathways through which glutamine can be utilized has grown more refined. Additionally, the different metabolic requirements of the diverse array of cell types within the tumor microenvironment complicate the strategy of targeting any particular glutamine pathway as cancer therapy. In this Mini-Review, we discuss recent advances in further clarifying the cellular fate of glutamine through different metabolic pathways. We further discuss potential promising strategies which exploit the different requirements of cells in the tumor microenvironment as it pertains to glutamine metabolism in an attempt to suppress cancer growth and enhance anti-tumor immune responses. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9531032/ /pubmed/36203456 http://dx.doi.org/10.3389/fonc.2022.1011191 Text en Copyright © 2022 Claiborne and Leone https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Claiborne, Michael D.
Leone, Robert
Differential glutamine metabolism in the tumor microenvironment – studies in diversity and heterogeneity: A mini-review
title Differential glutamine metabolism in the tumor microenvironment – studies in diversity and heterogeneity: A mini-review
title_full Differential glutamine metabolism in the tumor microenvironment – studies in diversity and heterogeneity: A mini-review
title_fullStr Differential glutamine metabolism in the tumor microenvironment – studies in diversity and heterogeneity: A mini-review
title_full_unstemmed Differential glutamine metabolism in the tumor microenvironment – studies in diversity and heterogeneity: A mini-review
title_short Differential glutamine metabolism in the tumor microenvironment – studies in diversity and heterogeneity: A mini-review
title_sort differential glutamine metabolism in the tumor microenvironment – studies in diversity and heterogeneity: a mini-review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531032/
https://www.ncbi.nlm.nih.gov/pubmed/36203456
http://dx.doi.org/10.3389/fonc.2022.1011191
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