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Single molecule microscopy reveals diverse actions of substrate sequences that impair ClpX AAA+ ATPase function

AAA+ (ATPases Associated with diverse cellular Activities) proteases unfold substrate proteins by pulling the substrate polypeptide through a narrow pore. To overcome the barrier to unfolding, substrates may require extended association with the ATPase. Failed unfolding attempts can lead to a slip o...

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Detalles Bibliográficos
Autores principales:	Wang, Xiao, Simon, Sanford M., Coffino, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531181/ https://www.ncbi.nlm.nih.gov/pubmed/36064000 http://dx.doi.org/10.1016/j.jbc.2022.102457

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