Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy

We report an easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon (IFN) concatemers with improved in vitro bioactivity, in vivo pharmacokinetics and therapeutic efficacy over the monomeric IFN, and the results can be positively enhanc...

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Detalles Bibliográficos
Autores principales: Hu, Jin, Shi, Jianquan, Yuan, Yeshuang, Li, Shengjie, Zhang, Bo, Dong, Haitao, Zhong, Qing, Xie, Qiu, Bai, Xiaoyin, Li, Yingxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531251/
https://www.ncbi.nlm.nih.gov/pubmed/36320276
http://dx.doi.org/10.1039/d2ra04978c
Descripción
Sumario:We report an easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon (IFN) concatemers with improved in vitro bioactivity, in vivo pharmacokinetics and therapeutic efficacy over the monomeric IFN, and the results can be positively enhanced by the concatenated number of self-fused proteins.

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