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Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy
We report an easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon (IFN) concatemers with improved in vitro bioactivity, in vivo pharmacokinetics and therapeutic efficacy over the monomeric IFN, and the results can be positively enhanc...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531251/ https://www.ncbi.nlm.nih.gov/pubmed/36320276 http://dx.doi.org/10.1039/d2ra04978c |
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author | Hu, Jin Shi, Jianquan Yuan, Yeshuang Li, Shengjie Zhang, Bo Dong, Haitao Zhong, Qing Xie, Qiu Bai, Xiaoyin Li, Yingxing |
author_facet | Hu, Jin Shi, Jianquan Yuan, Yeshuang Li, Shengjie Zhang, Bo Dong, Haitao Zhong, Qing Xie, Qiu Bai, Xiaoyin Li, Yingxing |
author_sort | Hu, Jin |
collection | PubMed |
description | We report an easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon (IFN) concatemers with improved in vitro bioactivity, in vivo pharmacokinetics and therapeutic efficacy over the monomeric IFN, and the results can be positively enhanced by the concatenated number of self-fused proteins. |
format | Online Article Text |
id | pubmed-9531251 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-95312512022-10-31 Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy Hu, Jin Shi, Jianquan Yuan, Yeshuang Li, Shengjie Zhang, Bo Dong, Haitao Zhong, Qing Xie, Qiu Bai, Xiaoyin Li, Yingxing RSC Adv Chemistry We report an easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon (IFN) concatemers with improved in vitro bioactivity, in vivo pharmacokinetics and therapeutic efficacy over the monomeric IFN, and the results can be positively enhanced by the concatenated number of self-fused proteins. The Royal Society of Chemistry 2022-10-04 /pmc/articles/PMC9531251/ /pubmed/36320276 http://dx.doi.org/10.1039/d2ra04978c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Hu, Jin Shi, Jianquan Yuan, Yeshuang Li, Shengjie Zhang, Bo Dong, Haitao Zhong, Qing Xie, Qiu Bai, Xiaoyin Li, Yingxing Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy |
title | Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy |
title_full | Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy |
title_fullStr | Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy |
title_full_unstemmed | Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy |
title_short | Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy |
title_sort | self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531251/ https://www.ncbi.nlm.nih.gov/pubmed/36320276 http://dx.doi.org/10.1039/d2ra04978c |
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