Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy

We report an easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon (IFN) concatemers with improved in vitro bioactivity, in vivo pharmacokinetics and therapeutic efficacy over the monomeric IFN, and the results can be positively enhanc...

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Detalles Bibliográficos
Autores principales: Hu, Jin, Shi, Jianquan, Yuan, Yeshuang, Li, Shengjie, Zhang, Bo, Dong, Haitao, Zhong, Qing, Xie, Qiu, Bai, Xiaoyin, Li, Yingxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531251/
https://www.ncbi.nlm.nih.gov/pubmed/36320276
http://dx.doi.org/10.1039/d2ra04978c
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author Hu, Jin
Shi, Jianquan
Yuan, Yeshuang
Li, Shengjie
Zhang, Bo
Dong, Haitao
Zhong, Qing
Xie, Qiu
Bai, Xiaoyin
Li, Yingxing
author_facet Hu, Jin
Shi, Jianquan
Yuan, Yeshuang
Li, Shengjie
Zhang, Bo
Dong, Haitao
Zhong, Qing
Xie, Qiu
Bai, Xiaoyin
Li, Yingxing
author_sort Hu, Jin
collection PubMed
description We report an easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon (IFN) concatemers with improved in vitro bioactivity, in vivo pharmacokinetics and therapeutic efficacy over the monomeric IFN, and the results can be positively enhanced by the concatenated number of self-fused proteins.
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spelling pubmed-95312512022-10-31 Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy Hu, Jin Shi, Jianquan Yuan, Yeshuang Li, Shengjie Zhang, Bo Dong, Haitao Zhong, Qing Xie, Qiu Bai, Xiaoyin Li, Yingxing RSC Adv Chemistry We report an easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon (IFN) concatemers with improved in vitro bioactivity, in vivo pharmacokinetics and therapeutic efficacy over the monomeric IFN, and the results can be positively enhanced by the concatenated number of self-fused proteins. The Royal Society of Chemistry 2022-10-04 /pmc/articles/PMC9531251/ /pubmed/36320276 http://dx.doi.org/10.1039/d2ra04978c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Hu, Jin
Shi, Jianquan
Yuan, Yeshuang
Li, Shengjie
Zhang, Bo
Dong, Haitao
Zhong, Qing
Xie, Qiu
Bai, Xiaoyin
Li, Yingxing
Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy
title Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy
title_full Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy
title_fullStr Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy
title_full_unstemmed Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy
title_short Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy
title_sort self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531251/
https://www.ncbi.nlm.nih.gov/pubmed/36320276
http://dx.doi.org/10.1039/d2ra04978c
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