Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy

We report an easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon (IFN) concatemers with improved in vitro bioactivity, in vivo pharmacokinetics and therapeutic efficacy over the monomeric IFN, and the results can be positively enhanc...

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Detalles Bibliográficos
Autores principales: Hu, Jin, Shi, Jianquan, Yuan, Yeshuang, Li, Shengjie, Zhang, Bo, Dong, Haitao, Zhong, Qing, Xie, Qiu, Bai, Xiaoyin, Li, Yingxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531251/
https://www.ncbi.nlm.nih.gov/pubmed/36320276
http://dx.doi.org/10.1039/d2ra04978c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531251/
https://www.ncbi.nlm.nih.gov/pubmed/36320276
http://dx.doi.org/10.1039/d2ra04978c

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