Vaginal bacterium Prevotella timonensis turns protective Langerhans cells into HIV‐1 reservoirs for virus dissemination

Dysbiosis of vaginal microbiota is associated with increased HIV‐1 acquisition, but the underlying cellular mechanisms remain unclear. Vaginal Langerhans cells (LCs) protect against mucosal HIV‐1 infection via autophagy‐mediated degradation of HIV‐1. As LCs are in continuous contact with bacterial m...

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Detalles Bibliográficos
Autores principales: van Teijlingen, Nienke H, Helgers, Leanne C, Sarrami‐Forooshani, Ramin, Zijlstra‐Willems, Esther M, van Hamme, John L, Segui‐Perez, Celia, van Smoorenburg, Marleen Y, Borgdorff, Hanneke, van de Wijgert, Janneke HHM, van Leeuwen, Elisabeth, van der Post, Joris AM, Strijbis, Karin, Ribeiro, Carla MS, Geijtenbeek, Teunis BH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531304/
https://www.ncbi.nlm.nih.gov/pubmed/35968812
http://dx.doi.org/10.15252/embj.2022110629

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