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Developmental errors in the common marmoset retina

Although retinal organization is remarkably conserved, morphological anomalies can be found to different extents and varieties across animal species with each presenting unique characteristics and patterns of displaced and misplaced neurons. One of the most widely used non-human primates in research...

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Autores principales: Haverkamp, Silke, Mietsch, Matthias, Briggman, Kevin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531312/
https://www.ncbi.nlm.nih.gov/pubmed/36204677
http://dx.doi.org/10.3389/fnana.2022.1000693
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author Haverkamp, Silke
Mietsch, Matthias
Briggman, Kevin L.
author_facet Haverkamp, Silke
Mietsch, Matthias
Briggman, Kevin L.
author_sort Haverkamp, Silke
collection PubMed
description Although retinal organization is remarkably conserved, morphological anomalies can be found to different extents and varieties across animal species with each presenting unique characteristics and patterns of displaced and misplaced neurons. One of the most widely used non-human primates in research, the common marmoset (Callithrix jaccus) could potentially also be of interest for visual research, but is unfortunately not well characterized in this regard. Therefore, the aim of our study was to provide a first time description of structural retinal layering including morphological differences and distinctive features in this species. Retinas from animals (n = 26) of both sexes and different ages were immunostained with cell specific antibodies to label a variety of bipolar, amacrine and ganglion cells. Misplaced ganglion cells with somata in the outermost part of the inner nuclear layer and rod bipolar cells with axon terminals projecting into the outer plexiform layer instead of the inner plexiform layer independent of age or sex of the animals were the most obvious findings, whereas misplaced amacrine cells and misplaced cone bipolar axon terminals occurred to a lesser extent. With this first time description of developmental retinal errors over a wide age range, we provide a basic characterization of the retinal system of the common marmosets, which can be taken into account for future studies in this and other animal species. The finding of misplaced ganglion cells and misplaced bipolar cell axon terminals was not reported before and displays an anatomic variation worthwhile for future analyzes of their physiological and functional impact.
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spelling pubmed-95313122022-10-05 Developmental errors in the common marmoset retina Haverkamp, Silke Mietsch, Matthias Briggman, Kevin L. Front Neuroanat Neuroscience Although retinal organization is remarkably conserved, morphological anomalies can be found to different extents and varieties across animal species with each presenting unique characteristics and patterns of displaced and misplaced neurons. One of the most widely used non-human primates in research, the common marmoset (Callithrix jaccus) could potentially also be of interest for visual research, but is unfortunately not well characterized in this regard. Therefore, the aim of our study was to provide a first time description of structural retinal layering including morphological differences and distinctive features in this species. Retinas from animals (n = 26) of both sexes and different ages were immunostained with cell specific antibodies to label a variety of bipolar, amacrine and ganglion cells. Misplaced ganglion cells with somata in the outermost part of the inner nuclear layer and rod bipolar cells with axon terminals projecting into the outer plexiform layer instead of the inner plexiform layer independent of age or sex of the animals were the most obvious findings, whereas misplaced amacrine cells and misplaced cone bipolar axon terminals occurred to a lesser extent. With this first time description of developmental retinal errors over a wide age range, we provide a basic characterization of the retinal system of the common marmosets, which can be taken into account for future studies in this and other animal species. The finding of misplaced ganglion cells and misplaced bipolar cell axon terminals was not reported before and displays an anatomic variation worthwhile for future analyzes of their physiological and functional impact. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9531312/ /pubmed/36204677 http://dx.doi.org/10.3389/fnana.2022.1000693 Text en Copyright © 2022 Haverkamp, Mietsch and Briggman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Haverkamp, Silke
Mietsch, Matthias
Briggman, Kevin L.
Developmental errors in the common marmoset retina
title Developmental errors in the common marmoset retina
title_full Developmental errors in the common marmoset retina
title_fullStr Developmental errors in the common marmoset retina
title_full_unstemmed Developmental errors in the common marmoset retina
title_short Developmental errors in the common marmoset retina
title_sort developmental errors in the common marmoset retina
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531312/
https://www.ncbi.nlm.nih.gov/pubmed/36204677
http://dx.doi.org/10.3389/fnana.2022.1000693
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