TNFα and IFNγ rapidly activate PI3K-AKT signaling to drive glycolysis that confers mesenchymal stem cells enhanced anti-inflammatory property

BACKGROUND: Mesenchymal stem/stromal cells (MSCs) acquire immunosuppressive capacity only in an inflammatory microenvironment. This can be recapitulated in vitro by treating MSCs with inflammatory cytokines TNFα and IFNγ, which induce indoleamine 2,3-dioxygenase (IDO) and TNF-stimulated gene-6 (TSG-...

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Detalles Bibliográficos
Autores principales: Xu, Chenchang, Feng, Chao, Huang, Peiqing, Li, Yinghong, Liu, Rui, Liu, Chunxiao, Han, Yuyi, Chen, Lei, Ding, Yayun, Shao, Changshun, Shi, Yufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531381/
https://www.ncbi.nlm.nih.gov/pubmed/36195887
http://dx.doi.org/10.1186/s13287-022-03178-3

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