ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis

BACKGROUND: Hepatic fibrosis is a common pathologic stage in chronic liver disease development, which might ultimately lead to liver cirrhosis. Accumulating evidence suggests that adipose-derived stromal cells (ADSCs)-based therapies show excellent therapeutic potential in liver injury disease owing...

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Detalles Bibliográficos
Autores principales: Wu, Baitong, Feng, Jiuxing, Guo, Jingyi, Wang, Jian, Xiu, Guanghui, Xu, Jiaqi, Ning, Ke, Ling, Bin, Fu, Qingchun, Xu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531400/
https://www.ncbi.nlm.nih.gov/pubmed/36195966
http://dx.doi.org/10.1186/s13287-022-03049-x

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