The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors

ABSTRACT: Clinical diagnostics rely heavily on the detection and quantification of cancer biomarkers. The rapid detection of cancer-specific biomarkers is of great importance in the early diagnosis of cancers and plays a crucial role in the subsequent treatments. There are several different detectio...

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Autores principales: Kamali, Hossein, Golmohammadzadeh, Shiva, Zare, Hamed, Nosrati, Rahim, Fereidouni, Mohammad, Safarpour, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531510/
https://www.ncbi.nlm.nih.gov/pubmed/36195928
http://dx.doi.org/10.1186/s12951-022-01640-1
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author Kamali, Hossein
Golmohammadzadeh, Shiva
Zare, Hamed
Nosrati, Rahim
Fereidouni, Mohammad
Safarpour, Hossein
author_facet Kamali, Hossein
Golmohammadzadeh, Shiva
Zare, Hamed
Nosrati, Rahim
Fereidouni, Mohammad
Safarpour, Hossein
author_sort Kamali, Hossein
collection PubMed
description ABSTRACT: Clinical diagnostics rely heavily on the detection and quantification of cancer biomarkers. The rapid detection of cancer-specific biomarkers is of great importance in the early diagnosis of cancers and plays a crucial role in the subsequent treatments. There are several different detection techniques available today for detecting cancer biomarkers. Because of target-related conformational alterations, high stability, and target variety, aptamers have received considerable interest as a biosensing system component. To date, several sensitivity-enhancement strategies have been used with a broad spectrum of nanomaterials and nanoparticles (NPs) to improve the limit and sensitivity of analyte detection in the construction of innovative aptasensors. The present article aims to outline the research developments on the potential of DNAzymes-based aptasensors for cancer biomarker detection. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-95315102022-10-05 The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors Kamali, Hossein Golmohammadzadeh, Shiva Zare, Hamed Nosrati, Rahim Fereidouni, Mohammad Safarpour, Hossein J Nanobiotechnology Review ABSTRACT: Clinical diagnostics rely heavily on the detection and quantification of cancer biomarkers. The rapid detection of cancer-specific biomarkers is of great importance in the early diagnosis of cancers and plays a crucial role in the subsequent treatments. There are several different detection techniques available today for detecting cancer biomarkers. Because of target-related conformational alterations, high stability, and target variety, aptamers have received considerable interest as a biosensing system component. To date, several sensitivity-enhancement strategies have been used with a broad spectrum of nanomaterials and nanoparticles (NPs) to improve the limit and sensitivity of analyte detection in the construction of innovative aptasensors. The present article aims to outline the research developments on the potential of DNAzymes-based aptasensors for cancer biomarker detection. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2022-10-04 /pmc/articles/PMC9531510/ /pubmed/36195928 http://dx.doi.org/10.1186/s12951-022-01640-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Kamali, Hossein
Golmohammadzadeh, Shiva
Zare, Hamed
Nosrati, Rahim
Fereidouni, Mohammad
Safarpour, Hossein
The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors
title The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors
title_full The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors
title_fullStr The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors
title_full_unstemmed The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors
title_short The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors
title_sort recent advancements in the early detection of cancer biomarkers by dnazyme-assisted aptasensors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531510/
https://www.ncbi.nlm.nih.gov/pubmed/36195928
http://dx.doi.org/10.1186/s12951-022-01640-1
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