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Pulmonary hypertension in patients with interstitial lung disease: a tool for early detection
Pulmonary hypertension (PH) complicates the treatment of interstitial lung disease (ILD) patients resulting in poor functional status and worse outcomes. Early recognition of PH in ILD is important for initiating therapy and considering lung transplantation. However, no standard exists regarding whi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531548/ https://www.ncbi.nlm.nih.gov/pubmed/36225536 http://dx.doi.org/10.1002/pul2.12141 |
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author | Parikh, Raj Konstantinidis, Ippokratis O'Sullivan, David M. Farber, Harrison W. |
author_facet | Parikh, Raj Konstantinidis, Ippokratis O'Sullivan, David M. Farber, Harrison W. |
author_sort | Parikh, Raj |
collection | PubMed |
description | Pulmonary hypertension (PH) complicates the treatment of interstitial lung disease (ILD) patients resulting in poor functional status and worse outcomes. Early recognition of PH in ILD is important for initiating therapy and considering lung transplantation. However, no standard exists regarding which patients to screen for PH‐ILD or the optimal method to do so. The aim of this study was to create a risk assessment tool that could reliably predict PH in ILD patients. We developed a PH‐ILD Detection tool that incorporated history, exam, 6‐min walk distance, diffusion capacity for carbon monoxide, chest imaging, and cardiac biomarkers to create an eight‐component score. This tool was analyzed retrospectively in 154 ILD patients where each patient was given a score ranging from 0 to 12. The sensitivity (SN) and specificity (SP) of the PH‐ILD Detection tool and an area‐under‐the‐curve (AUC) were calculated. In this cohort, 74 patients (48.1%) had PH‐ILD. A score of ≥6 on the PH‐ILD Detection tool was associated with a diagnosis of PH‐ILD (SN: 86.5%; SP: 86.3%; area‐under‐the‐curve: 0.920, p < 0.001). The PH‐ILD Detection tool provides high SN and SP for detecting PH in ILD patients. With confirmation in larger cohorts, this tool could improve the diagnosis of PH in ILD and may suggest further testing with right heart catheterization and earlier intervention with inhaled treprostinil and/or lung transplant evaluation. |
format | Online Article Text |
id | pubmed-9531548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95315482022-10-11 Pulmonary hypertension in patients with interstitial lung disease: a tool for early detection Parikh, Raj Konstantinidis, Ippokratis O'Sullivan, David M. Farber, Harrison W. Pulm Circ Research Articles Pulmonary hypertension (PH) complicates the treatment of interstitial lung disease (ILD) patients resulting in poor functional status and worse outcomes. Early recognition of PH in ILD is important for initiating therapy and considering lung transplantation. However, no standard exists regarding which patients to screen for PH‐ILD or the optimal method to do so. The aim of this study was to create a risk assessment tool that could reliably predict PH in ILD patients. We developed a PH‐ILD Detection tool that incorporated history, exam, 6‐min walk distance, diffusion capacity for carbon monoxide, chest imaging, and cardiac biomarkers to create an eight‐component score. This tool was analyzed retrospectively in 154 ILD patients where each patient was given a score ranging from 0 to 12. The sensitivity (SN) and specificity (SP) of the PH‐ILD Detection tool and an area‐under‐the‐curve (AUC) were calculated. In this cohort, 74 patients (48.1%) had PH‐ILD. A score of ≥6 on the PH‐ILD Detection tool was associated with a diagnosis of PH‐ILD (SN: 86.5%; SP: 86.3%; area‐under‐the‐curve: 0.920, p < 0.001). The PH‐ILD Detection tool provides high SN and SP for detecting PH in ILD patients. With confirmation in larger cohorts, this tool could improve the diagnosis of PH in ILD and may suggest further testing with right heart catheterization and earlier intervention with inhaled treprostinil and/or lung transplant evaluation. John Wiley and Sons Inc. 2022-10-01 /pmc/articles/PMC9531548/ /pubmed/36225536 http://dx.doi.org/10.1002/pul2.12141 Text en © 2022 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Parikh, Raj Konstantinidis, Ippokratis O'Sullivan, David M. Farber, Harrison W. Pulmonary hypertension in patients with interstitial lung disease: a tool for early detection |
title | Pulmonary hypertension in patients with interstitial lung disease: a tool for early detection |
title_full | Pulmonary hypertension in patients with interstitial lung disease: a tool for early detection |
title_fullStr | Pulmonary hypertension in patients with interstitial lung disease: a tool for early detection |
title_full_unstemmed | Pulmonary hypertension in patients with interstitial lung disease: a tool for early detection |
title_short | Pulmonary hypertension in patients with interstitial lung disease: a tool for early detection |
title_sort | pulmonary hypertension in patients with interstitial lung disease: a tool for early detection |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531548/ https://www.ncbi.nlm.nih.gov/pubmed/36225536 http://dx.doi.org/10.1002/pul2.12141 |
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