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Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

Biomimetic materials for better bone graft substitutes are a thrust area of research among researchers and clinicians. Autografts, allografts, and synthetic grafts are often utilized to repair and regenerate bone defects. Autografts are still considered the gold-standard method/material to treat bon...

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Autores principales: Kim, Se-Kwon, Murugan, Sesha Subramanian, Dalavi, Pandurang Appana, Gupta, Sebanti, Anil, Sukumaran, Seong, Gi Hun, Venkatesan, Jayachandran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531556/
https://www.ncbi.nlm.nih.gov/pubmed/36247529
http://dx.doi.org/10.3762/bjnano.13.92
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author Kim, Se-Kwon
Murugan, Sesha Subramanian
Dalavi, Pandurang Appana
Gupta, Sebanti
Anil, Sukumaran
Seong, Gi Hun
Venkatesan, Jayachandran
author_facet Kim, Se-Kwon
Murugan, Sesha Subramanian
Dalavi, Pandurang Appana
Gupta, Sebanti
Anil, Sukumaran
Seong, Gi Hun
Venkatesan, Jayachandran
author_sort Kim, Se-Kwon
collection PubMed
description Biomimetic materials for better bone graft substitutes are a thrust area of research among researchers and clinicians. Autografts, allografts, and synthetic grafts are often utilized to repair and regenerate bone defects. Autografts are still considered the gold-standard method/material to treat bone-related issues with satisfactory outcomes. It is important that the material used for bone tissue repair is simultaneously osteoconductive, osteoinductive, and osteogenic. To overcome this problem, researchers have tried several ways to develop different materials using chitosan-based nanocomposites of silver, copper, gold, zinc oxide, titanium oxide, carbon nanotubes, graphene oxide, and biosilica. The combination of materials helps in the expression of ideal bone formation genes of alkaline phosphatase, bone morphogenic protein, runt-related transcription factor-2, bone sialoprotein, and osteocalcin. In vitro and in vivo studies highlight the scientific findings of antibacterial activity, tissue integration, stiffness, mechanical strength, and degradation behaviour of composite materials for tissue engineering applications.
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spelling pubmed-95315562022-10-13 Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration Kim, Se-Kwon Murugan, Sesha Subramanian Dalavi, Pandurang Appana Gupta, Sebanti Anil, Sukumaran Seong, Gi Hun Venkatesan, Jayachandran Beilstein J Nanotechnol Review Biomimetic materials for better bone graft substitutes are a thrust area of research among researchers and clinicians. Autografts, allografts, and synthetic grafts are often utilized to repair and regenerate bone defects. Autografts are still considered the gold-standard method/material to treat bone-related issues with satisfactory outcomes. It is important that the material used for bone tissue repair is simultaneously osteoconductive, osteoinductive, and osteogenic. To overcome this problem, researchers have tried several ways to develop different materials using chitosan-based nanocomposites of silver, copper, gold, zinc oxide, titanium oxide, carbon nanotubes, graphene oxide, and biosilica. The combination of materials helps in the expression of ideal bone formation genes of alkaline phosphatase, bone morphogenic protein, runt-related transcription factor-2, bone sialoprotein, and osteocalcin. In vitro and in vivo studies highlight the scientific findings of antibacterial activity, tissue integration, stiffness, mechanical strength, and degradation behaviour of composite materials for tissue engineering applications. Beilstein-Institut 2022-09-29 /pmc/articles/PMC9531556/ /pubmed/36247529 http://dx.doi.org/10.3762/bjnano.13.92 Text en Copyright © 2022, Kim et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjnano/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Review
Kim, Se-Kwon
Murugan, Sesha Subramanian
Dalavi, Pandurang Appana
Gupta, Sebanti
Anil, Sukumaran
Seong, Gi Hun
Venkatesan, Jayachandran
Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration
title Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration
title_full Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration
title_fullStr Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration
title_full_unstemmed Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration
title_short Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration
title_sort biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531556/
https://www.ncbi.nlm.nih.gov/pubmed/36247529
http://dx.doi.org/10.3762/bjnano.13.92
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