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Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration
Biomimetic materials for better bone graft substitutes are a thrust area of research among researchers and clinicians. Autografts, allografts, and synthetic grafts are often utilized to repair and regenerate bone defects. Autografts are still considered the gold-standard method/material to treat bon...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Beilstein-Institut
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531556/ https://www.ncbi.nlm.nih.gov/pubmed/36247529 http://dx.doi.org/10.3762/bjnano.13.92 |
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author | Kim, Se-Kwon Murugan, Sesha Subramanian Dalavi, Pandurang Appana Gupta, Sebanti Anil, Sukumaran Seong, Gi Hun Venkatesan, Jayachandran |
author_facet | Kim, Se-Kwon Murugan, Sesha Subramanian Dalavi, Pandurang Appana Gupta, Sebanti Anil, Sukumaran Seong, Gi Hun Venkatesan, Jayachandran |
author_sort | Kim, Se-Kwon |
collection | PubMed |
description | Biomimetic materials for better bone graft substitutes are a thrust area of research among researchers and clinicians. Autografts, allografts, and synthetic grafts are often utilized to repair and regenerate bone defects. Autografts are still considered the gold-standard method/material to treat bone-related issues with satisfactory outcomes. It is important that the material used for bone tissue repair is simultaneously osteoconductive, osteoinductive, and osteogenic. To overcome this problem, researchers have tried several ways to develop different materials using chitosan-based nanocomposites of silver, copper, gold, zinc oxide, titanium oxide, carbon nanotubes, graphene oxide, and biosilica. The combination of materials helps in the expression of ideal bone formation genes of alkaline phosphatase, bone morphogenic protein, runt-related transcription factor-2, bone sialoprotein, and osteocalcin. In vitro and in vivo studies highlight the scientific findings of antibacterial activity, tissue integration, stiffness, mechanical strength, and degradation behaviour of composite materials for tissue engineering applications. |
format | Online Article Text |
id | pubmed-9531556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-95315562022-10-13 Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration Kim, Se-Kwon Murugan, Sesha Subramanian Dalavi, Pandurang Appana Gupta, Sebanti Anil, Sukumaran Seong, Gi Hun Venkatesan, Jayachandran Beilstein J Nanotechnol Review Biomimetic materials for better bone graft substitutes are a thrust area of research among researchers and clinicians. Autografts, allografts, and synthetic grafts are often utilized to repair and regenerate bone defects. Autografts are still considered the gold-standard method/material to treat bone-related issues with satisfactory outcomes. It is important that the material used for bone tissue repair is simultaneously osteoconductive, osteoinductive, and osteogenic. To overcome this problem, researchers have tried several ways to develop different materials using chitosan-based nanocomposites of silver, copper, gold, zinc oxide, titanium oxide, carbon nanotubes, graphene oxide, and biosilica. The combination of materials helps in the expression of ideal bone formation genes of alkaline phosphatase, bone morphogenic protein, runt-related transcription factor-2, bone sialoprotein, and osteocalcin. In vitro and in vivo studies highlight the scientific findings of antibacterial activity, tissue integration, stiffness, mechanical strength, and degradation behaviour of composite materials for tissue engineering applications. Beilstein-Institut 2022-09-29 /pmc/articles/PMC9531556/ /pubmed/36247529 http://dx.doi.org/10.3762/bjnano.13.92 Text en Copyright © 2022, Kim et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjnano/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material. |
spellingShingle | Review Kim, Se-Kwon Murugan, Sesha Subramanian Dalavi, Pandurang Appana Gupta, Sebanti Anil, Sukumaran Seong, Gi Hun Venkatesan, Jayachandran Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration |
title | Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration |
title_full | Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration |
title_fullStr | Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration |
title_full_unstemmed | Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration |
title_short | Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration |
title_sort | biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531556/ https://www.ncbi.nlm.nih.gov/pubmed/36247529 http://dx.doi.org/10.3762/bjnano.13.92 |
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