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Sarcomatoid Carcinoma of the Ascending Colon: A Case Report and Literature Review

Patient: Female, 77-year-old Final Diagnosis: Sarcomatoid carcinoma Symptoms: Abdominal pain • abdominal distension • fever • nausea Medication: — Clinical Procedure:— Specialty: Surgery OBJECTIVE: Rare disease BACKGROUND: Sarcomatoid carcinoma is a rare tumor that can occur in different organs and...

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Autores principales: Naser, Zachary J., Morrissey, Shawna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531627/
https://www.ncbi.nlm.nih.gov/pubmed/36176184
http://dx.doi.org/10.12659/AJCR.937548
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author Naser, Zachary J.
Morrissey, Shawna
author_facet Naser, Zachary J.
Morrissey, Shawna
author_sort Naser, Zachary J.
collection PubMed
description Patient: Female, 77-year-old Final Diagnosis: Sarcomatoid carcinoma Symptoms: Abdominal pain • abdominal distension • fever • nausea Medication: — Clinical Procedure:— Specialty: Surgery OBJECTIVE: Rare disease BACKGROUND: Sarcomatoid carcinoma is a rare tumor that can occur in different organs and anatomical locations. Colonic sarcomatoid carcinoma, also known as carcinosarcoma, is an extremely rare tumor, with only 32 cases reported world-wide. The pathogenesis and guidelines for treatment are poorly understood due to the rarity and invasiveness of the disease. CASE REPORT: A 77-year-old woman presented with worsening lower abdominal pain and associated fever after having initially been diagnosed with stump appendicitis and associated phlegmon 3 weeks prior, which was treated with antibiotics. Repeat imaging revealed an extraluminal versus perforated colonic mass with associated phlegmon. The patient’s condition continued to worsen, with development of obstructive-like symptoms, resulting in operative intervention involving a R2 right hemicolectomy, stapled ileo-colostomy, and partial omentectomy. The patient had an uneventful remainder of her hospitalization other than continued lower abdominal pain. After initial discharge, the patient presented to an outside hospital due to continued deterioration of health, with findings of an additional mass, likely secondary to the previous lymphadenopathy. Ultimately, goals of care were discussed, and the decision was made to provide palliative care, and the patient died due to her illness 32 days after the initial procedure. CONCLUSIONS: Carcinosarcoma is an extremely rare tumor with scant research guiding treatment guidelines. Current guidelines gathered from previous case reports suggest treating colorectal carcinosarcoma as adenocarcinoma. Additional research and studies are needed to establish appropriate therapeutic guidelines for carcinosarcoma.
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spelling pubmed-95316272022-10-26 Sarcomatoid Carcinoma of the Ascending Colon: A Case Report and Literature Review Naser, Zachary J. Morrissey, Shawna Am J Case Rep Articles Patient: Female, 77-year-old Final Diagnosis: Sarcomatoid carcinoma Symptoms: Abdominal pain • abdominal distension • fever • nausea Medication: — Clinical Procedure:— Specialty: Surgery OBJECTIVE: Rare disease BACKGROUND: Sarcomatoid carcinoma is a rare tumor that can occur in different organs and anatomical locations. Colonic sarcomatoid carcinoma, also known as carcinosarcoma, is an extremely rare tumor, with only 32 cases reported world-wide. The pathogenesis and guidelines for treatment are poorly understood due to the rarity and invasiveness of the disease. CASE REPORT: A 77-year-old woman presented with worsening lower abdominal pain and associated fever after having initially been diagnosed with stump appendicitis and associated phlegmon 3 weeks prior, which was treated with antibiotics. Repeat imaging revealed an extraluminal versus perforated colonic mass with associated phlegmon. The patient’s condition continued to worsen, with development of obstructive-like symptoms, resulting in operative intervention involving a R2 right hemicolectomy, stapled ileo-colostomy, and partial omentectomy. The patient had an uneventful remainder of her hospitalization other than continued lower abdominal pain. After initial discharge, the patient presented to an outside hospital due to continued deterioration of health, with findings of an additional mass, likely secondary to the previous lymphadenopathy. Ultimately, goals of care were discussed, and the decision was made to provide palliative care, and the patient died due to her illness 32 days after the initial procedure. CONCLUSIONS: Carcinosarcoma is an extremely rare tumor with scant research guiding treatment guidelines. Current guidelines gathered from previous case reports suggest treating colorectal carcinosarcoma as adenocarcinoma. Additional research and studies are needed to establish appropriate therapeutic guidelines for carcinosarcoma. International Scientific Literature, Inc. 2022-09-30 /pmc/articles/PMC9531627/ /pubmed/36176184 http://dx.doi.org/10.12659/AJCR.937548 Text en © Am J Case Rep, 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Naser, Zachary J.
Morrissey, Shawna
Sarcomatoid Carcinoma of the Ascending Colon: A Case Report and Literature Review
title Sarcomatoid Carcinoma of the Ascending Colon: A Case Report and Literature Review
title_full Sarcomatoid Carcinoma of the Ascending Colon: A Case Report and Literature Review
title_fullStr Sarcomatoid Carcinoma of the Ascending Colon: A Case Report and Literature Review
title_full_unstemmed Sarcomatoid Carcinoma of the Ascending Colon: A Case Report and Literature Review
title_short Sarcomatoid Carcinoma of the Ascending Colon: A Case Report and Literature Review
title_sort sarcomatoid carcinoma of the ascending colon: a case report and literature review
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531627/
https://www.ncbi.nlm.nih.gov/pubmed/36176184
http://dx.doi.org/10.12659/AJCR.937548
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