Dynamic covalent chemistry with azines

Dynamic covalent chemistry is used in many applications that require both the stability of covalent bonds and the possibility to exchange building blocks. Here we present azines as a dynamic covalent functional group that combines the best characteristics of imines and acylhydrazones. We show that a...

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Autores principales: Dascalu, Anca-Elena, Halgreen, Lau, Torres-Huerta, Aaron, Valkenier, Hennie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531658/
https://www.ncbi.nlm.nih.gov/pubmed/36102679
http://dx.doi.org/10.1039/d2cc03523e
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author Dascalu, Anca-Elena
Halgreen, Lau
Torres-Huerta, Aaron
Valkenier, Hennie
author_facet Dascalu, Anca-Elena
Halgreen, Lau
Torres-Huerta, Aaron
Valkenier, Hennie
author_sort Dascalu, Anca-Elena
collection PubMed
description Dynamic covalent chemistry is used in many applications that require both the stability of covalent bonds and the possibility to exchange building blocks. Here we present azines as a dynamic covalent functional group that combines the best characteristics of imines and acylhydrazones. We show that azines are stable in the presence of water and that dynamic combinatorial libraries of azines and aldehydes equilibrate in less than an hour.
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spelling pubmed-95316582022-10-31 Dynamic covalent chemistry with azines Dascalu, Anca-Elena Halgreen, Lau Torres-Huerta, Aaron Valkenier, Hennie Chem Commun (Camb) Chemistry Dynamic covalent chemistry is used in many applications that require both the stability of covalent bonds and the possibility to exchange building blocks. Here we present azines as a dynamic covalent functional group that combines the best characteristics of imines and acylhydrazones. We show that azines are stable in the presence of water and that dynamic combinatorial libraries of azines and aldehydes equilibrate in less than an hour. The Royal Society of Chemistry 2022-09-08 /pmc/articles/PMC9531658/ /pubmed/36102679 http://dx.doi.org/10.1039/d2cc03523e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Dascalu, Anca-Elena
Halgreen, Lau
Torres-Huerta, Aaron
Valkenier, Hennie
Dynamic covalent chemistry with azines
title Dynamic covalent chemistry with azines
title_full Dynamic covalent chemistry with azines
title_fullStr Dynamic covalent chemistry with azines
title_full_unstemmed Dynamic covalent chemistry with azines
title_short Dynamic covalent chemistry with azines
title_sort dynamic covalent chemistry with azines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531658/
https://www.ncbi.nlm.nih.gov/pubmed/36102679
http://dx.doi.org/10.1039/d2cc03523e
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AT halgreenlau dynamiccovalentchemistrywithazines
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