A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors

Decoration of cap on viral RNA plays essential roles in SARS-CoV-2 proliferation. Here, we report a mechanism for SARS-CoV-2 RNA capping and document structural details at atomic resolution. The NiRAN domain in polymerase catalyzes the covalent link of RNA 5′ end to the first residue of nsp9 (termed...

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Detalles Bibliográficos
Autores principales: Yan, Liming, Huang, Yucen, Ge, Ji, Liu, Zhenyu, Lu, Pengchi, Huang, Bo, Gao, Shan, Wang, Junbo, Tan, Liping, Ye, Sihan, Yu, Fengxi, Lan, Weiqi, Xu, Shiya, Zhou, Feng, Shi, Lei, Guddat, Luke W., Gao, Yan, Rao, Zihe, Lou, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531661/
https://www.ncbi.nlm.nih.gov/pubmed/36335936
http://dx.doi.org/10.1016/j.cell.2022.09.037

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