Increased sIL-2Rα leads to obstruction of IL-2 biological function and Treg cells differentiation in SLE patients via binding to IL-2

BACKGROUND: The decrease of IL-2 level is believed to play an important role in the disease occurrence and development of SLE, but the relevant mechanisms have not been fully clarified. Many studies have found that the level of soluble interleukin 2 receptor α (sIL-2Rα) in SLE patients is significan...

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Detalles Bibliográficos
Autores principales: Long, Dan, Yu, Shujiao, Zhang, Lu, Guo, Yang, Xu, Shumin, Rao, Yuting, Huang, Zikun, Luo, Qing, Li, Junming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531682/
https://www.ncbi.nlm.nih.gov/pubmed/36203602
http://dx.doi.org/10.3389/fimmu.2022.938556

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