Combined inhibition of BCR-ABL1 and the proteasome as a potential novel therapeutic approach in BCR-ABL positive acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is a disease of lymphoid progenitor cells with an often aggressive course and is commonly caused by the BCR-ABL fusion gene t(9;22) in adults. This fusion gene encodes a constitutively active tyrosine kinase that can be effectively inhibited by tyrosine kinase inhi...

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Detalles Bibliográficos
Autores principales: Maletzke, Saskia, Salimi, Azam, Vieri, Margherita, Schroeder, Kema Marlen, Schemionek, Mirle, Masouleh, Behzad Kharabi, Brümmendorf, Tim H., Koschmieder, Steffen, Appelmann, Iris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531817/
https://www.ncbi.nlm.nih.gov/pubmed/36194587
http://dx.doi.org/10.1371/journal.pone.0268352

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