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Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice
One purified neutral polysaccharide fraction was obtained from the rhizome of Polygonatum sibiricum by DEAE ion exchange and gel chromatography. Structure elucidation was performed by methanolysis, methylation, FT-IR, and NMR. The results indicated that PSP-NP was composed of 1,4-β-D-Gal,1, 4, 6-β-D...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531825/ https://www.ncbi.nlm.nih.gov/pubmed/36204377 http://dx.doi.org/10.3389/fnut.2022.992102 |
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author | Li, Li-Xia Feng, Xin Tao, Meng-Ting Paulsen, Berit Smestad Huang, Chao Feng, Bin Liu, Wei Yin, Zhong-Qiong Song, Xu Zhao, Xinghong Liang, Xiao-Xia Yin, Li-Zi Tang, Hua-Qiao Zou, Yuan-Feng |
author_facet | Li, Li-Xia Feng, Xin Tao, Meng-Ting Paulsen, Berit Smestad Huang, Chao Feng, Bin Liu, Wei Yin, Zhong-Qiong Song, Xu Zhao, Xinghong Liang, Xiao-Xia Yin, Li-Zi Tang, Hua-Qiao Zou, Yuan-Feng |
author_sort | Li, Li-Xia |
collection | PubMed |
description | One purified neutral polysaccharide fraction was obtained from the rhizome of Polygonatum sibiricum by DEAE ion exchange and gel chromatography. Structure elucidation was performed by methanolysis, methylation, FT-IR, and NMR. The results indicated that PSP-NP was composed of 1,4-β-D-Gal,1, 4, 6-β-D-Gal, T-α-D-Man,1, 4-α-D-Glc, and T-α-D-Glc with a molecular weight of 43.0 kDa. We supplied this polysaccharide to aged mice and found it is of benefits to intestinal functions, as indicated by better tissue integrity and motility, improved oxidative stress and inflammation, reduced intestinal permeability and serum LPS level, as well as balanced gut microbial composition and short-chain fatty acids production. These results display a novel Polygonatum sibiricum polysaccharide to improve the intestinal function of aged mice, which provides pieces of evidence for its further development and utilization. |
format | Online Article Text |
id | pubmed-9531825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95318252022-10-05 Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice Li, Li-Xia Feng, Xin Tao, Meng-Ting Paulsen, Berit Smestad Huang, Chao Feng, Bin Liu, Wei Yin, Zhong-Qiong Song, Xu Zhao, Xinghong Liang, Xiao-Xia Yin, Li-Zi Tang, Hua-Qiao Zou, Yuan-Feng Front Nutr Nutrition One purified neutral polysaccharide fraction was obtained from the rhizome of Polygonatum sibiricum by DEAE ion exchange and gel chromatography. Structure elucidation was performed by methanolysis, methylation, FT-IR, and NMR. The results indicated that PSP-NP was composed of 1,4-β-D-Gal,1, 4, 6-β-D-Gal, T-α-D-Man,1, 4-α-D-Glc, and T-α-D-Glc with a molecular weight of 43.0 kDa. We supplied this polysaccharide to aged mice and found it is of benefits to intestinal functions, as indicated by better tissue integrity and motility, improved oxidative stress and inflammation, reduced intestinal permeability and serum LPS level, as well as balanced gut microbial composition and short-chain fatty acids production. These results display a novel Polygonatum sibiricum polysaccharide to improve the intestinal function of aged mice, which provides pieces of evidence for its further development and utilization. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9531825/ /pubmed/36204377 http://dx.doi.org/10.3389/fnut.2022.992102 Text en Copyright © 2022 Li, Feng, Tao, Paulsen, Huang, Feng, Liu, Yin, Song, Zhao, Liang, Yin, Tang and Zou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Li, Li-Xia Feng, Xin Tao, Meng-Ting Paulsen, Berit Smestad Huang, Chao Feng, Bin Liu, Wei Yin, Zhong-Qiong Song, Xu Zhao, Xinghong Liang, Xiao-Xia Yin, Li-Zi Tang, Hua-Qiao Zou, Yuan-Feng Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice |
title | Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice |
title_full | Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice |
title_fullStr | Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice |
title_full_unstemmed | Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice |
title_short | Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice |
title_sort | benefits of neutral polysaccharide from rhizomes of polygonatum sibiricum to intestinal function of aged mice |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531825/ https://www.ncbi.nlm.nih.gov/pubmed/36204377 http://dx.doi.org/10.3389/fnut.2022.992102 |
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