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Role of Sirtuins in Diabetes and Age-Related Processes

The practice of intermittent fasting continues to grow as a widely practiced diet trend due to its feasibility and reported high success rate. By practicing intermittent fasting, levels of sirtuin proteins (SIRTs), also known as the longevity protein, rise in the body and bring numerous health benef...

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Detalles Bibliográficos
Autores principales: Lingappa, Nimisha, Mayrovitz, Harvey N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531907/
https://www.ncbi.nlm.nih.gov/pubmed/36225477
http://dx.doi.org/10.7759/cureus.28774
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author Lingappa, Nimisha
Mayrovitz, Harvey N
author_facet Lingappa, Nimisha
Mayrovitz, Harvey N
author_sort Lingappa, Nimisha
collection PubMed
description The practice of intermittent fasting continues to grow as a widely practiced diet trend due to its feasibility and reported high success rate. By practicing intermittent fasting, levels of sirtuin proteins (SIRTs), also known as the longevity protein, rise in the body and bring numerous health benefits. Currently, seven SIRTs have been described in humans in different locations of the cell with a wide variety of corresponding functions including gene transcription, DNA repair, and protection against oxidative damage. SIRT activators, such as resveratrol found in red wine, are also commonly consumed to amplify the health benefits associated with protection against diabetes and age-related disease processes. The purpose of this review is to explore the interaction of intermittent fasting on SIRT levels and how the increase in these proteins impacts age-related disease processes. The understanding of SIRTs is continuously evolving as more interactions and SIRT-specific activators are being revealed. New discoveries are crucial for forming potential therapeutics that delay many common diseases and promote healthy living. 
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spelling pubmed-95319072022-10-11 Role of Sirtuins in Diabetes and Age-Related Processes Lingappa, Nimisha Mayrovitz, Harvey N Cureus Cardiology The practice of intermittent fasting continues to grow as a widely practiced diet trend due to its feasibility and reported high success rate. By practicing intermittent fasting, levels of sirtuin proteins (SIRTs), also known as the longevity protein, rise in the body and bring numerous health benefits. Currently, seven SIRTs have been described in humans in different locations of the cell with a wide variety of corresponding functions including gene transcription, DNA repair, and protection against oxidative damage. SIRT activators, such as resveratrol found in red wine, are also commonly consumed to amplify the health benefits associated with protection against diabetes and age-related disease processes. The purpose of this review is to explore the interaction of intermittent fasting on SIRT levels and how the increase in these proteins impacts age-related disease processes. The understanding of SIRTs is continuously evolving as more interactions and SIRT-specific activators are being revealed. New discoveries are crucial for forming potential therapeutics that delay many common diseases and promote healthy living.  Cureus 2022-09-04 /pmc/articles/PMC9531907/ /pubmed/36225477 http://dx.doi.org/10.7759/cureus.28774 Text en Copyright © 2022, Lingappa et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Lingappa, Nimisha
Mayrovitz, Harvey N
Role of Sirtuins in Diabetes and Age-Related Processes
title Role of Sirtuins in Diabetes and Age-Related Processes
title_full Role of Sirtuins in Diabetes and Age-Related Processes
title_fullStr Role of Sirtuins in Diabetes and Age-Related Processes
title_full_unstemmed Role of Sirtuins in Diabetes and Age-Related Processes
title_short Role of Sirtuins in Diabetes and Age-Related Processes
title_sort role of sirtuins in diabetes and age-related processes
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531907/
https://www.ncbi.nlm.nih.gov/pubmed/36225477
http://dx.doi.org/10.7759/cureus.28774
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