Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models

Trans-differentiation of hepatic stellate cells (HSCs) to activated state potentiates liver fibrosis through release of extracellular matrix (ECM) components, distorting the liver architecture. Since limited antifibrotics are available, pharmacological intervention targeting activated HSCs may be co...

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Detalles Bibliográficos
Autores principales: Ramani, Komal, Mavila, Nirmala, Abeynayake, Aushinie, Tomasi, Maria Lauda, Wang, Jiaohong, Matsuda, Michitaka, Seki, Eki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531947/
https://www.ncbi.nlm.nih.gov/pubmed/36193675
http://dx.doi.org/10.7554/eLife.78430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531947/
https://www.ncbi.nlm.nih.gov/pubmed/36193675
http://dx.doi.org/10.7554/eLife.78430

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