High-throughput nanopore sequencing of Treponema pallidum tandem repeat genes arp and tp0470 reveals clade-specific patterns and recapitulates global whole genome phylogeny

Sequencing of most Treponema pallidum genomes excludes repeat regions in tp0470 and the tp0433 gene, encoding the acidic repeat protein (arp). As a first step to understanding the evolution and function of these genes and the proteins they encode, we developed a protocol to nanopore sequence tp0470...

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Detalles Bibliográficos
Autores principales: Lieberman, Nicole A. P., Armstrong, Thaddeus D., Chung, Benjamin, Pfalmer, Daniel, Hennelly, Christopher M., Haynes, Austin, Romeis, Emily, Wang, Qian-Qiu, Zhang, Rui-Li, Kou, Cai-Xia, Ciccarese, Giulia, Conte, Ivano Dal, Cusini, Marco, Drago, Francesco, Nakayama, Shu-ichi, Lee, Kenichi, Ohnishi, Makoto, Konda, Kelika A., Vargas, Silver K., Eguiluz, Maria, Caceres, Carlos F., Klausner, Jeffrey D., Mitja, Oriol, Rompalo, Anne, Mulcahy, Fiona, Hook, Edward W., Hoffman, Irving F., Matoga, Mitch M., Zheng, Heping, Yang, Bin, Lopez-Medina, Eduardo, Ramirez, Lady G., Radolf, Justin D., Hawley, Kelly L., Salazar, Juan C., Lukehart, Sheila A., Seña, Arlene C., Parr, Jonathan B., Giacani, Lorenzo, Greninger, Alexander L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531955/
https://www.ncbi.nlm.nih.gov/pubmed/36204625
http://dx.doi.org/10.3389/fmicb.2022.1007056

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