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Surfactancy in a tadpole model of proteins
We model the environment of eukaryotic nuclei by representing macromolecules by only their entropic properties, with globular molecules represented by spherical colloids and flexible molecules by polymers. We put particular focus on proteins with both globular and intrinsically disordered regions, w...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532023/ https://www.ncbi.nlm.nih.gov/pubmed/36195115 http://dx.doi.org/10.1098/rsif.2022.0172 |
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author | Dyer, O. T. Ball, R. C. |
author_facet | Dyer, O. T. Ball, R. C. |
author_sort | Dyer, O. T. |
collection | PubMed |
description | We model the environment of eukaryotic nuclei by representing macromolecules by only their entropic properties, with globular molecules represented by spherical colloids and flexible molecules by polymers. We put particular focus on proteins with both globular and intrinsically disordered regions, which we represent with ‘tadpole’ constructed by grafting single polymers and colloids together. In Monte Carlo simulations, we find these tadpoles support phase separation via depletion flocculation, and demonstrate several surfactant behaviours, including being found preferentially at interfaces and forming micelles in single phase solution. Furthermore, the model parameters can be tuned to give a tadpole a preference for either bulk phase. However, we find entropy too weak to drive these behaviours by itself at likely biological concentrations. |
format | Online Article Text |
id | pubmed-9532023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-95320232022-10-14 Surfactancy in a tadpole model of proteins Dyer, O. T. Ball, R. C. J R Soc Interface Life Sciences–Physics interface We model the environment of eukaryotic nuclei by representing macromolecules by only their entropic properties, with globular molecules represented by spherical colloids and flexible molecules by polymers. We put particular focus on proteins with both globular and intrinsically disordered regions, which we represent with ‘tadpole’ constructed by grafting single polymers and colloids together. In Monte Carlo simulations, we find these tadpoles support phase separation via depletion flocculation, and demonstrate several surfactant behaviours, including being found preferentially at interfaces and forming micelles in single phase solution. Furthermore, the model parameters can be tuned to give a tadpole a preference for either bulk phase. However, we find entropy too weak to drive these behaviours by itself at likely biological concentrations. The Royal Society 2022-10-05 /pmc/articles/PMC9532023/ /pubmed/36195115 http://dx.doi.org/10.1098/rsif.2022.0172 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Life Sciences–Physics interface Dyer, O. T. Ball, R. C. Surfactancy in a tadpole model of proteins |
title | Surfactancy in a tadpole model of proteins |
title_full | Surfactancy in a tadpole model of proteins |
title_fullStr | Surfactancy in a tadpole model of proteins |
title_full_unstemmed | Surfactancy in a tadpole model of proteins |
title_short | Surfactancy in a tadpole model of proteins |
title_sort | surfactancy in a tadpole model of proteins |
topic | Life Sciences–Physics interface |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532023/ https://www.ncbi.nlm.nih.gov/pubmed/36195115 http://dx.doi.org/10.1098/rsif.2022.0172 |
work_keys_str_mv | AT dyerot surfactancyinatadpolemodelofproteins AT ballrc surfactancyinatadpolemodelofproteins |