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The Prognostic Value of Serum Apolipoprotein A-I Level and Neutrophil-to-Lymphocyte Ratio in Colorectal Cancer Liver Metastasis

BACKGROUND: Colorectal cancer liver metastasis (CRLM) is a high degree of malignancy with rapid disease progression and has a poor prognosis. Both serum apolipoprotein A-I (ApoA-I) and neutrophil-to-lymphocyte ratio (NLR) play key roles in anti-inflammation and antitumor. This study is aimed at eval...

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Autores principales: Fang, Chongkai, Huang, Yue, Chen, Chuyao, Nie, Duorui, Lin, Jietao, Xiao, Zhiwei, Li, Saimei, Liu, Silin, Luo, Rui, Lin, Hongtong, Zhong, Chong, Huang, Xuewu, Shao, Cui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532097/
https://www.ncbi.nlm.nih.gov/pubmed/36204177
http://dx.doi.org/10.1155/2022/9149788
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author Fang, Chongkai
Huang, Yue
Chen, Chuyao
Nie, Duorui
Lin, Jietao
Xiao, Zhiwei
Li, Saimei
Liu, Silin
Luo, Rui
Lin, Hongtong
Zhong, Chong
Huang, Xuewu
Shao, Cui
author_facet Fang, Chongkai
Huang, Yue
Chen, Chuyao
Nie, Duorui
Lin, Jietao
Xiao, Zhiwei
Li, Saimei
Liu, Silin
Luo, Rui
Lin, Hongtong
Zhong, Chong
Huang, Xuewu
Shao, Cui
author_sort Fang, Chongkai
collection PubMed
description BACKGROUND: Colorectal cancer liver metastasis (CRLM) is a high degree of malignancy with rapid disease progression and has a poor prognosis. Both serum apolipoprotein A-I (ApoA-I) and neutrophil-to-lymphocyte ratio (NLR) play key roles in anti-inflammation and antitumor. This study is aimed at evaluating the implication of serum ApoA-I level in combination with NLR in the prognosis of CRLM. METHODS: We retrospectively analyzed the serum ApoA-I level and NLR in 237 patients with CRLM. Cox regression analyses were used to identify the independent prognostic significance of these indicators. Kaplan-Meier method and Log-rank test were applied to compute overall survival (OS). Both the ApoA-I and NLR were divided into three levels, according to their medians. A risk-stratified prediction model was established to evaluate the prognosis of patients with CRLM. The ROC curve AUC values were applied to evaluate the capability of the model. RESULTS: Higher levels of ApoA-I and lower NLR were strongly associated with prolonged OS (Log-rank test, P < 0.05). The patients were then grouped into three queues according to the ApoA-I level and NLR. There was a crucial diversity in the OS (P < 0.001) between the high-risk (ApoA − I ≤ 1.03 g/L and NLR > 3.24), medium-risk (ApoA − I > 1.03 g/L or NLR ≤ 3.24) and low-risk groups (ApoA − I > 1.03 g/L and NLR ≤ 3.24). The AUC value of the prediction model (AUC = 0.623, 95% CI: 0.557-0.639, P = 0.001) was higher than other individual indicators (including ApoA-I, NLR, cT classification, and cN classification). Additionally, the association of the prediction model and cTN classification (AUC = 0.715, 95% CI: 0.606-0.708, P < 0.001) was better than the model and cTN classification alone. CONCLUSION: The combination of ApoA-I level and NLR could be a prognostic indicator for CRLM.
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spelling pubmed-95320972022-10-05 The Prognostic Value of Serum Apolipoprotein A-I Level and Neutrophil-to-Lymphocyte Ratio in Colorectal Cancer Liver Metastasis Fang, Chongkai Huang, Yue Chen, Chuyao Nie, Duorui Lin, Jietao Xiao, Zhiwei Li, Saimei Liu, Silin Luo, Rui Lin, Hongtong Zhong, Chong Huang, Xuewu Shao, Cui J Oncol Research Article BACKGROUND: Colorectal cancer liver metastasis (CRLM) is a high degree of malignancy with rapid disease progression and has a poor prognosis. Both serum apolipoprotein A-I (ApoA-I) and neutrophil-to-lymphocyte ratio (NLR) play key roles in anti-inflammation and antitumor. This study is aimed at evaluating the implication of serum ApoA-I level in combination with NLR in the prognosis of CRLM. METHODS: We retrospectively analyzed the serum ApoA-I level and NLR in 237 patients with CRLM. Cox regression analyses were used to identify the independent prognostic significance of these indicators. Kaplan-Meier method and Log-rank test were applied to compute overall survival (OS). Both the ApoA-I and NLR were divided into three levels, according to their medians. A risk-stratified prediction model was established to evaluate the prognosis of patients with CRLM. The ROC curve AUC values were applied to evaluate the capability of the model. RESULTS: Higher levels of ApoA-I and lower NLR were strongly associated with prolonged OS (Log-rank test, P < 0.05). The patients were then grouped into three queues according to the ApoA-I level and NLR. There was a crucial diversity in the OS (P < 0.001) between the high-risk (ApoA − I ≤ 1.03 g/L and NLR > 3.24), medium-risk (ApoA − I > 1.03 g/L or NLR ≤ 3.24) and low-risk groups (ApoA − I > 1.03 g/L and NLR ≤ 3.24). The AUC value of the prediction model (AUC = 0.623, 95% CI: 0.557-0.639, P = 0.001) was higher than other individual indicators (including ApoA-I, NLR, cT classification, and cN classification). Additionally, the association of the prediction model and cTN classification (AUC = 0.715, 95% CI: 0.606-0.708, P < 0.001) was better than the model and cTN classification alone. CONCLUSION: The combination of ApoA-I level and NLR could be a prognostic indicator for CRLM. Hindawi 2022-09-27 /pmc/articles/PMC9532097/ /pubmed/36204177 http://dx.doi.org/10.1155/2022/9149788 Text en Copyright © 2022 Chongkai Fang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fang, Chongkai
Huang, Yue
Chen, Chuyao
Nie, Duorui
Lin, Jietao
Xiao, Zhiwei
Li, Saimei
Liu, Silin
Luo, Rui
Lin, Hongtong
Zhong, Chong
Huang, Xuewu
Shao, Cui
The Prognostic Value of Serum Apolipoprotein A-I Level and Neutrophil-to-Lymphocyte Ratio in Colorectal Cancer Liver Metastasis
title The Prognostic Value of Serum Apolipoprotein A-I Level and Neutrophil-to-Lymphocyte Ratio in Colorectal Cancer Liver Metastasis
title_full The Prognostic Value of Serum Apolipoprotein A-I Level and Neutrophil-to-Lymphocyte Ratio in Colorectal Cancer Liver Metastasis
title_fullStr The Prognostic Value of Serum Apolipoprotein A-I Level and Neutrophil-to-Lymphocyte Ratio in Colorectal Cancer Liver Metastasis
title_full_unstemmed The Prognostic Value of Serum Apolipoprotein A-I Level and Neutrophil-to-Lymphocyte Ratio in Colorectal Cancer Liver Metastasis
title_short The Prognostic Value of Serum Apolipoprotein A-I Level and Neutrophil-to-Lymphocyte Ratio in Colorectal Cancer Liver Metastasis
title_sort prognostic value of serum apolipoprotein a-i level and neutrophil-to-lymphocyte ratio in colorectal cancer liver metastasis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532097/
https://www.ncbi.nlm.nih.gov/pubmed/36204177
http://dx.doi.org/10.1155/2022/9149788
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