Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications

Pyroptosis is an inflammatory form of programmed cell death that is dependent on inflammatory caspases, leading to the cleavage of gasdermin D (GSDMD) and increased secretion of interleukin (IL)-1β and IL-18. Recent studies have reported that hyperglycemia-induced cellular stress stimulates pyroptos...

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Detalles Bibliográficos
Autores principales: Gu, Junling, Geng, Kang, Guo, Man, Huang, Wei, Zhao, Tingting, Li, Xuling, Xu, You-Hua, Xu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532106/
https://www.ncbi.nlm.nih.gov/pubmed/36204129
http://dx.doi.org/10.1155/2022/5277673
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author Gu, Junling
Geng, Kang
Guo, Man
Huang, Wei
Zhao, Tingting
Li, Xuling
Xu, You-Hua
Xu, Yong
author_facet Gu, Junling
Geng, Kang
Guo, Man
Huang, Wei
Zhao, Tingting
Li, Xuling
Xu, You-Hua
Xu, Yong
author_sort Gu, Junling
collection PubMed
description Pyroptosis is an inflammatory form of programmed cell death that is dependent on inflammatory caspases, leading to the cleavage of gasdermin D (GSDMD) and increased secretion of interleukin (IL)-1β and IL-18. Recent studies have reported that hyperglycemia-induced cellular stress stimulates pyroptosis, and different signaling pathways have been shown to play crucial roles in regulating pyroptosis. This review summarized and discussed the molecular mechanisms, regulation, and cellular effects of pyroptosis in diabetic microvascular complications, such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. In addition, this review aimed to provide new insights into identifying better treatments for diabetic microvascular complications.
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spelling pubmed-95321062022-10-05 Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications Gu, Junling Geng, Kang Guo, Man Huang, Wei Zhao, Tingting Li, Xuling Xu, You-Hua Xu, Yong Evid Based Complement Alternat Med Review Article Pyroptosis is an inflammatory form of programmed cell death that is dependent on inflammatory caspases, leading to the cleavage of gasdermin D (GSDMD) and increased secretion of interleukin (IL)-1β and IL-18. Recent studies have reported that hyperglycemia-induced cellular stress stimulates pyroptosis, and different signaling pathways have been shown to play crucial roles in regulating pyroptosis. This review summarized and discussed the molecular mechanisms, regulation, and cellular effects of pyroptosis in diabetic microvascular complications, such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. In addition, this review aimed to provide new insights into identifying better treatments for diabetic microvascular complications. Hindawi 2022-09-27 /pmc/articles/PMC9532106/ /pubmed/36204129 http://dx.doi.org/10.1155/2022/5277673 Text en Copyright © 2022 Junling Gu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gu, Junling
Geng, Kang
Guo, Man
Huang, Wei
Zhao, Tingting
Li, Xuling
Xu, You-Hua
Xu, Yong
Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications
title Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications
title_full Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications
title_fullStr Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications
title_full_unstemmed Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications
title_short Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications
title_sort targeting pyroptosis: new insights into the treatment of diabetic microvascular complications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532106/
https://www.ncbi.nlm.nih.gov/pubmed/36204129
http://dx.doi.org/10.1155/2022/5277673
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