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Association between Serum Lipid Levels and Sensorineural Hearing Loss in Korean Adult Population

BACKGROUND: Hearing loss (HL) has been suggested to be associated with impaired microcirculation of the inner ear. This cross-sectional study aimed to evaluate an association between HL and serum lipid levels. METHODS: The study comprised 10,356 Korean adults who participated in the fifth Korea Nati...

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Autores principales: Jung, Wonyoung, Kim, Jiyoung, Cho, In Young, Jeon, Keun Hye, Song, Yun-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Academy of Family Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532192/
https://www.ncbi.nlm.nih.gov/pubmed/36168906
http://dx.doi.org/10.4082/kjfm.21.0148
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author Jung, Wonyoung
Kim, Jiyoung
Cho, In Young
Jeon, Keun Hye
Song, Yun-Mi
author_facet Jung, Wonyoung
Kim, Jiyoung
Cho, In Young
Jeon, Keun Hye
Song, Yun-Mi
author_sort Jung, Wonyoung
collection PubMed
description BACKGROUND: Hearing loss (HL) has been suggested to be associated with impaired microcirculation of the inner ear. This cross-sectional study aimed to evaluate an association between HL and serum lipid levels. METHODS: The study comprised 10,356 Korean adults who participated in the fifth Korea National Health and Nutrition Examination Survey (2010–2012). We defined HL as the average hearing thresholds exceeding 25 dB at predetermined frequency levels by pure tone audiometry. Serum lipid levels were measured using an enzymatic assay. The associations between lipid levels and HL were evaluated using a multiple logistic regression model after adjusting for covariates including age, sex, hypertension, diabetes, smoking status, alcohol, physical activity, educational level, household income, and noise exposure. Stratified analyses were performed to examine the effect of the covariates on the association between lipid levels and HL. RESULTS: The high-density lipoprotein cholesterol (HDL-C) level was inversely associated with high-frequency (HF)-HL, with an odds ratio (95% confidence interval) of 0.78 (0.64–0.96) for 1-mmol/L increase in the HDL-C level. Neither the triglyceride nor the low-density lipoprotein cholesterol level was associated with HF-HL. For low-frequency HL, association with any of the serum lipid components was absent. A stratified analysis showed that the inverse association between HDL-C levels and HF-HL was evident (P trend <0.05) in some subjects with specific characteristics such as older age (≥65 years), female sex, non-hypertensive state, and non-regular physical activity. However, a significant interaction between HDL-C levels and all of the stratified variables was absent (P for interaction >0.05). CONCLUSION: The HDL-C level has a linear inverse association with the risk of HF-HL. Given the known protective role of HDL-C against atherosclerotic changes, this finding seems to support the concept of impaired microcirculation in the inner ear as a mechanism for HF-HL.
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spelling pubmed-95321922022-10-11 Association between Serum Lipid Levels and Sensorineural Hearing Loss in Korean Adult Population Jung, Wonyoung Kim, Jiyoung Cho, In Young Jeon, Keun Hye Song, Yun-Mi Korean J Fam Med Original Article BACKGROUND: Hearing loss (HL) has been suggested to be associated with impaired microcirculation of the inner ear. This cross-sectional study aimed to evaluate an association between HL and serum lipid levels. METHODS: The study comprised 10,356 Korean adults who participated in the fifth Korea National Health and Nutrition Examination Survey (2010–2012). We defined HL as the average hearing thresholds exceeding 25 dB at predetermined frequency levels by pure tone audiometry. Serum lipid levels were measured using an enzymatic assay. The associations between lipid levels and HL were evaluated using a multiple logistic regression model after adjusting for covariates including age, sex, hypertension, diabetes, smoking status, alcohol, physical activity, educational level, household income, and noise exposure. Stratified analyses were performed to examine the effect of the covariates on the association between lipid levels and HL. RESULTS: The high-density lipoprotein cholesterol (HDL-C) level was inversely associated with high-frequency (HF)-HL, with an odds ratio (95% confidence interval) of 0.78 (0.64–0.96) for 1-mmol/L increase in the HDL-C level. Neither the triglyceride nor the low-density lipoprotein cholesterol level was associated with HF-HL. For low-frequency HL, association with any of the serum lipid components was absent. A stratified analysis showed that the inverse association between HDL-C levels and HF-HL was evident (P trend <0.05) in some subjects with specific characteristics such as older age (≥65 years), female sex, non-hypertensive state, and non-regular physical activity. However, a significant interaction between HDL-C levels and all of the stratified variables was absent (P for interaction >0.05). CONCLUSION: The HDL-C level has a linear inverse association with the risk of HF-HL. Given the known protective role of HDL-C against atherosclerotic changes, this finding seems to support the concept of impaired microcirculation in the inner ear as a mechanism for HF-HL. Korean Academy of Family Medicine 2022-09 2022-09-20 /pmc/articles/PMC9532192/ /pubmed/36168906 http://dx.doi.org/10.4082/kjfm.21.0148 Text en Copyright © 2022 The Korean Academy of Family Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jung, Wonyoung
Kim, Jiyoung
Cho, In Young
Jeon, Keun Hye
Song, Yun-Mi
Association between Serum Lipid Levels and Sensorineural Hearing Loss in Korean Adult Population
title Association between Serum Lipid Levels and Sensorineural Hearing Loss in Korean Adult Population
title_full Association between Serum Lipid Levels and Sensorineural Hearing Loss in Korean Adult Population
title_fullStr Association between Serum Lipid Levels and Sensorineural Hearing Loss in Korean Adult Population
title_full_unstemmed Association between Serum Lipid Levels and Sensorineural Hearing Loss in Korean Adult Population
title_short Association between Serum Lipid Levels and Sensorineural Hearing Loss in Korean Adult Population
title_sort association between serum lipid levels and sensorineural hearing loss in korean adult population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532192/
https://www.ncbi.nlm.nih.gov/pubmed/36168906
http://dx.doi.org/10.4082/kjfm.21.0148
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