Cargando…

Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation

Data on the influence of different Anti-lymphocyte globulin (ATLG) doses on graft versus host disease (GVHD) incidence and immune reconstitution in matched unrelated (MUD) allogeneic Stem cell transplantation (allo-SCT) is limited. This retrospective study conducted at the University Medical-Center...

Descripción completa

Detalles Bibliográficos
Autores principales: Massoud, Radwan, Klyuchnikov, Evgeny, Gagelmann, Nico, Zabelina, Tatiana, Wolschke, Christine, Ayuk, Francis, Fritzsche-Friedland, Ulrike, Zander, Axel, Kröger, Nicolaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532245/
https://www.ncbi.nlm.nih.gov/pubmed/35831408
http://dx.doi.org/10.1038/s41409-022-01666-x
_version_ 1784802078109990912
author Massoud, Radwan
Klyuchnikov, Evgeny
Gagelmann, Nico
Zabelina, Tatiana
Wolschke, Christine
Ayuk, Francis
Fritzsche-Friedland, Ulrike
Zander, Axel
Kröger, Nicolaus
author_facet Massoud, Radwan
Klyuchnikov, Evgeny
Gagelmann, Nico
Zabelina, Tatiana
Wolschke, Christine
Ayuk, Francis
Fritzsche-Friedland, Ulrike
Zander, Axel
Kröger, Nicolaus
author_sort Massoud, Radwan
collection PubMed
description Data on the influence of different Anti-lymphocyte globulin (ATLG) doses on graft versus host disease (GVHD) incidence and immune reconstitution in matched unrelated (MUD) allogeneic Stem cell transplantation (allo-SCT) is limited. This retrospective study conducted at the University Medical-Center Hamburg compares GVHD and Immune reconstitution after myeloablative MUD (HLA 10/10) PBSC allogeneic stem cell transplant between 30 mg/Kg (n = 73) and 60 mg/Kg (n = 216) ATLG. Detailed phenotypes of T, B natural killer (NK), natural killer T (NKT) cells were analyzed by multicolor flow at day 30, 100, and 180 posttransplant. Neutrophil and platelet engraftments were significantly delayed in the 60 mg/kg group with a higher Cumulative incidence of Infections (67% vs 75% p = 0.049) and EBV (21% vs 41% p = 0.049) reactivation at day 100 in this group. In the 30 mg/kg group, we observed a faster reconstitution of naïve-B cells (p < 0.0001) and γδ T cells (p = 0.045) at day+30 and a faster naïve helper T-cell (p = 0.046), NK-cells (p = 0.035), and naïve B-cell reconstitution (p = 0.009) at day+180. There were no significant differences in aGVHD, cGVHD, NRM, RI, PFS, and OS between the groups. The choice of ATLG dose has significant impact on IR but not on GVHD after MUD-allo-SCT. Higher doses are associated with delayed engraftment and increased infections.
format Online
Article
Text
id pubmed-9532245
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-95322452022-10-06 Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation Massoud, Radwan Klyuchnikov, Evgeny Gagelmann, Nico Zabelina, Tatiana Wolschke, Christine Ayuk, Francis Fritzsche-Friedland, Ulrike Zander, Axel Kröger, Nicolaus Bone Marrow Transplant Article Data on the influence of different Anti-lymphocyte globulin (ATLG) doses on graft versus host disease (GVHD) incidence and immune reconstitution in matched unrelated (MUD) allogeneic Stem cell transplantation (allo-SCT) is limited. This retrospective study conducted at the University Medical-Center Hamburg compares GVHD and Immune reconstitution after myeloablative MUD (HLA 10/10) PBSC allogeneic stem cell transplant between 30 mg/Kg (n = 73) and 60 mg/Kg (n = 216) ATLG. Detailed phenotypes of T, B natural killer (NK), natural killer T (NKT) cells were analyzed by multicolor flow at day 30, 100, and 180 posttransplant. Neutrophil and platelet engraftments were significantly delayed in the 60 mg/kg group with a higher Cumulative incidence of Infections (67% vs 75% p = 0.049) and EBV (21% vs 41% p = 0.049) reactivation at day 100 in this group. In the 30 mg/kg group, we observed a faster reconstitution of naïve-B cells (p < 0.0001) and γδ T cells (p = 0.045) at day+30 and a faster naïve helper T-cell (p = 0.046), NK-cells (p = 0.035), and naïve B-cell reconstitution (p = 0.009) at day+180. There were no significant differences in aGVHD, cGVHD, NRM, RI, PFS, and OS between the groups. The choice of ATLG dose has significant impact on IR but not on GVHD after MUD-allo-SCT. Higher doses are associated with delayed engraftment and increased infections. Nature Publishing Group UK 2022-07-13 2022 /pmc/articles/PMC9532245/ /pubmed/35831408 http://dx.doi.org/10.1038/s41409-022-01666-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Massoud, Radwan
Klyuchnikov, Evgeny
Gagelmann, Nico
Zabelina, Tatiana
Wolschke, Christine
Ayuk, Francis
Fritzsche-Friedland, Ulrike
Zander, Axel
Kröger, Nicolaus
Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation
title Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation
title_full Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation
title_fullStr Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation
title_full_unstemmed Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation
title_short Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation
title_sort impact of anti-t-lymphocyte globulin dosing on gvhd and immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532245/
https://www.ncbi.nlm.nih.gov/pubmed/35831408
http://dx.doi.org/10.1038/s41409-022-01666-x
work_keys_str_mv AT massoudradwan impactofantitlymphocyteglobulindosingongvhdandimmunereconstitutioninmatchedunrelatedmyeloablativeperipheralbloodstemcelltransplantation
AT klyuchnikovevgeny impactofantitlymphocyteglobulindosingongvhdandimmunereconstitutioninmatchedunrelatedmyeloablativeperipheralbloodstemcelltransplantation
AT gagelmannnico impactofantitlymphocyteglobulindosingongvhdandimmunereconstitutioninmatchedunrelatedmyeloablativeperipheralbloodstemcelltransplantation
AT zabelinatatiana impactofantitlymphocyteglobulindosingongvhdandimmunereconstitutioninmatchedunrelatedmyeloablativeperipheralbloodstemcelltransplantation
AT wolschkechristine impactofantitlymphocyteglobulindosingongvhdandimmunereconstitutioninmatchedunrelatedmyeloablativeperipheralbloodstemcelltransplantation
AT ayukfrancis impactofantitlymphocyteglobulindosingongvhdandimmunereconstitutioninmatchedunrelatedmyeloablativeperipheralbloodstemcelltransplantation
AT fritzschefriedlandulrike impactofantitlymphocyteglobulindosingongvhdandimmunereconstitutioninmatchedunrelatedmyeloablativeperipheralbloodstemcelltransplantation
AT zanderaxel impactofantitlymphocyteglobulindosingongvhdandimmunereconstitutioninmatchedunrelatedmyeloablativeperipheralbloodstemcelltransplantation
AT krogernicolaus impactofantitlymphocyteglobulindosingongvhdandimmunereconstitutioninmatchedunrelatedmyeloablativeperipheralbloodstemcelltransplantation