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Physical activity and risk of multiple sclerosis: A Mendelian randomization study
Multiple evidence from epidemiological studies has suggested association between physical activity and risk of multiple sclerosis (MS). However, the conclusion was still controversial between studies, and whether the association was causal or confounded is elusive. To evaluate the role of physical a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532251/ https://www.ncbi.nlm.nih.gov/pubmed/36211369 http://dx.doi.org/10.3389/fimmu.2022.872126 |
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author | Li, Chunyu Lin, Junyu Yang, Tianmi Xiao, Yi Jiang, Qirui Shang, Huifang |
author_facet | Li, Chunyu Lin, Junyu Yang, Tianmi Xiao, Yi Jiang, Qirui Shang, Huifang |
author_sort | Li, Chunyu |
collection | PubMed |
description | Multiple evidence from epidemiological studies has suggested association between physical activity and risk of multiple sclerosis (MS). However, the conclusion was still controversial between studies, and whether the association was causal or confounded is elusive. To evaluate the role of physical activity with different intensities in the risk of MS, we first estimated their genetic correlation, and then conducted two-sample and multivariable Mendelian randomization analyses based on summary statistics from previous large genome-wide association studies. A significant genetic correlation was identified between moderate physical activity and the risk of MS (genetic correlation: -0.15, SE=0.05, P=2.9E-03). Meanwhile, higher moderate physical activity was significantly associated with a reduced risk of MS (OR:0.87, 95% CI:0.80-0.96, P=3.45E-03). Such association was further verified using summary statistics from another study on overall physical activity (OR:0.36, 95% CI:0.17-0.76, P=6.82E-03). The results were robust under all sensitivity analyses. Current results suggested moderate physical activity could reduce the risk of MS. These findings help better understand the role of physical activity in MS, and provide some lifestyle recommendations for individuals susceptible to MS. |
format | Online Article Text |
id | pubmed-9532251 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95322512022-10-06 Physical activity and risk of multiple sclerosis: A Mendelian randomization study Li, Chunyu Lin, Junyu Yang, Tianmi Xiao, Yi Jiang, Qirui Shang, Huifang Front Immunol Immunology Multiple evidence from epidemiological studies has suggested association between physical activity and risk of multiple sclerosis (MS). However, the conclusion was still controversial between studies, and whether the association was causal or confounded is elusive. To evaluate the role of physical activity with different intensities in the risk of MS, we first estimated their genetic correlation, and then conducted two-sample and multivariable Mendelian randomization analyses based on summary statistics from previous large genome-wide association studies. A significant genetic correlation was identified between moderate physical activity and the risk of MS (genetic correlation: -0.15, SE=0.05, P=2.9E-03). Meanwhile, higher moderate physical activity was significantly associated with a reduced risk of MS (OR:0.87, 95% CI:0.80-0.96, P=3.45E-03). Such association was further verified using summary statistics from another study on overall physical activity (OR:0.36, 95% CI:0.17-0.76, P=6.82E-03). The results were robust under all sensitivity analyses. Current results suggested moderate physical activity could reduce the risk of MS. These findings help better understand the role of physical activity in MS, and provide some lifestyle recommendations for individuals susceptible to MS. Frontiers Media S.A. 2022-09-21 /pmc/articles/PMC9532251/ /pubmed/36211369 http://dx.doi.org/10.3389/fimmu.2022.872126 Text en Copyright © 2022 Li, Lin, Yang, Xiao, Jiang and Shang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Li, Chunyu Lin, Junyu Yang, Tianmi Xiao, Yi Jiang, Qirui Shang, Huifang Physical activity and risk of multiple sclerosis: A Mendelian randomization study |
title | Physical activity and risk of multiple sclerosis: A Mendelian randomization study |
title_full | Physical activity and risk of multiple sclerosis: A Mendelian randomization study |
title_fullStr | Physical activity and risk of multiple sclerosis: A Mendelian randomization study |
title_full_unstemmed | Physical activity and risk of multiple sclerosis: A Mendelian randomization study |
title_short | Physical activity and risk of multiple sclerosis: A Mendelian randomization study |
title_sort | physical activity and risk of multiple sclerosis: a mendelian randomization study |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532251/ https://www.ncbi.nlm.nih.gov/pubmed/36211369 http://dx.doi.org/10.3389/fimmu.2022.872126 |
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