Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease

Acute kidney injury (AKI) is frequent, often fatal and, for lack of specific therapies, can leave survivors with chronic kidney disease (CKD). We characterize the distribution of tubular cells (TC) undergoing polyploidy along AKI by DNA content analysis and single cell RNA-sequencing. Furthermore, w...

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Detalles Bibliográficos
Autores principales: De Chiara, Letizia, Conte, Carolina, Semeraro, Roberto, Diaz-Bulnes, Paula, Angelotti, Maria Lucia, Mazzinghi, Benedetta, Molli, Alice, Antonelli, Giulia, Landini, Samuela, Melica, Maria Elena, Peired, Anna Julie, Maggi, Laura, Donati, Marta, La Regina, Gilda, Allinovi, Marco, Ravaglia, Fiammetta, Guasti, Daniele, Bani, Daniele, Cirillo, Luigi, Becherucci, Francesca, Guzzi, Francesco, Magi, Alberto, Annunziato, Francesco, Lasagni, Laura, Anders, Hans-Joachim, Lazzeri, Elena, Romagnani, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532438/
https://www.ncbi.nlm.nih.gov/pubmed/36195583
http://dx.doi.org/10.1038/s41467-022-33110-5

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