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The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects

BACKGROUND: The mandible is a functional bio-organ that supports facial structures and helps mastication and speaking. Large mandible defects, generally greater than 6-cm segment loss, may require composite tissue reconstruction such as osteocutaneous-vascularized free flap which has a limitation of...

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Autores principales: Park, Han Ick, Lee, Jee-Ho, Lee, Sang Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532487/
https://www.ncbi.nlm.nih.gov/pubmed/36195777
http://dx.doi.org/10.1186/s40902-022-00361-7
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author Park, Han Ick
Lee, Jee-Ho
Lee, Sang Jin
author_facet Park, Han Ick
Lee, Jee-Ho
Lee, Sang Jin
author_sort Park, Han Ick
collection PubMed
description BACKGROUND: The mandible is a functional bio-organ that supports facial structures and helps mastication and speaking. Large mandible defects, generally greater than 6-cm segment loss, may require composite tissue reconstruction such as osteocutaneous-vascularized free flap which has a limitation of additional surgery and a functional morbidity at the donor site. A 3D bio-printing technology is recently developed to overcome the limitation in the composite reconstruction of the mandible using osteocutaneous-vascularized free flap. REVIEW: Scaffold, cells, and bioactive molecules are essential for a 3D bio-printing. For mandibular reconstruction, materials in a 3D bio-printing require mechanical strength, resilience, and biocompatibility. Recently, an integrated tissue and organ printing system with multiple cartridges are designed and it is capable of printing polymers to reinforce the printed structure, such as hydrogel. CONCLUSION: For successful composite tissue reconstruction of the mandible, biologic considerations and components should be presented with a comprehensive on-demand online platform model of customized approaches.
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spelling pubmed-95324872022-10-06 The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects Park, Han Ick Lee, Jee-Ho Lee, Sang Jin Maxillofac Plast Reconstr Surg Review BACKGROUND: The mandible is a functional bio-organ that supports facial structures and helps mastication and speaking. Large mandible defects, generally greater than 6-cm segment loss, may require composite tissue reconstruction such as osteocutaneous-vascularized free flap which has a limitation of additional surgery and a functional morbidity at the donor site. A 3D bio-printing technology is recently developed to overcome the limitation in the composite reconstruction of the mandible using osteocutaneous-vascularized free flap. REVIEW: Scaffold, cells, and bioactive molecules are essential for a 3D bio-printing. For mandibular reconstruction, materials in a 3D bio-printing require mechanical strength, resilience, and biocompatibility. Recently, an integrated tissue and organ printing system with multiple cartridges are designed and it is capable of printing polymers to reinforce the printed structure, such as hydrogel. CONCLUSION: For successful composite tissue reconstruction of the mandible, biologic considerations and components should be presented with a comprehensive on-demand online platform model of customized approaches. Springer Nature Singapore 2022-10-04 /pmc/articles/PMC9532487/ /pubmed/36195777 http://dx.doi.org/10.1186/s40902-022-00361-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Park, Han Ick
Lee, Jee-Ho
Lee, Sang Jin
The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects
title The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects
title_full The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects
title_fullStr The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects
title_full_unstemmed The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects
title_short The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects
title_sort comprehensive on-demand 3d bio-printing for composite reconstruction of mandibular defects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532487/
https://www.ncbi.nlm.nih.gov/pubmed/36195777
http://dx.doi.org/10.1186/s40902-022-00361-7
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